About: Decreased FEV (1)% in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values

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About: Decreased FEV (1)% in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decreased FEV (1)% in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values
Creator	Thomson, N Vesper, S Chaudhuri, R Howieson, S Mcsharry, C Wright, G Wymer, L
Source	PMC
abstract	BACKGROUND: Exposures to indoor biological contaminants have been implicated in asthma's aetiology but their effect on lung function is not well quantified. OBJECTIVE: The aim of this cross‐sectional study of non‐smoking, asthmatic adults in Scotland was to determine the correlation between the results from a standard spirometry test, forced expiratory volume in one‐second percent (FEV (1)%), and quantitative estimates of some biological exposures. METHODS: A population (n = 55) of non‐smoking, adult asthmatics in Scotland was included in this study and each completed a questionnaire that allowed the determination of the Asthma Control Questionnaire scores (ACQ) and St. George's Respiratory Questionnaire scores (SGRQ), as well as corticosteroid use. Spirometry testing was completed and the pre‐bronchodilator FEV (1)% value calculated. At about the same time, floor dust samples were collected in the living room and in the bedroom. These dust samples were analysed for mould contamination, as described by the Environmental Relative Moldiness Index (ERMI) values and by (1, 3)‐β‐D‐glucan concentrations, for endotoxin, and for dust mite, cat, and dog allergen concentrations. The asthmatics' FEV (1)% values were tested for correlation (Pearson) to questionnaire‐based estimates of health. Also, each biological exposure was tested for correlation (Pearson) to the FEV (1)% values. RESULTS: FEV (1)% results were correlated with ACQ scores (ρ −0.586, P < 0.001), SGRQ scores (ρ −0.313, P = 0.020), and weakly with corticosteroid use (ρ −0.221, P = 0.105). The ERMI values in the homes (average 5.3) were significantly correlated with FEV (1)% values (ρ −0.378, P = 0.004). There was no correlation between FEV (1)% and concentrations of endotoxin, (1, 3)‐β‐D‐glucan, or any of the allergens. CONCLUSION AND CLINICAL RELEVANCE: Although these results do not prove that mould exposures caused the deficit in lung function observed in this study, it might be advisable for asthmatics to avoid high ERMI environments.
has issue date	2015-04-16(xsd:dateTime)
bibo:doi	10.1111/cea.12482
bibo:pmid	25580663
has license	no-cc
sha1sum (hex)	c91f21cf133b4b9e4d6a725d0dc05b4083a20bbe
schema:url	https://doi.org/10.1111/cea.12482
resource representing a document's title	Decreased FEV (1)% in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values
has PubMed Central identifier	PMC7162076
has PubMed identifier	25580663
schema:publication	Clin Exp Allergy
resource representing a document's body	covid:c91f21cf133b4b9e4d6a725d0dc05b4083a20bbe#body_text
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