About: Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)

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About: Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)
Creator	Bont, Louis Engelhard, Dan Ashkar, Jalal Bamberger, Ellen Boico, Olga Braverman, Itzhak Chistyakov, Irena Cohen, Asi Dotan, Yaniv Eden, Eran Etshtein, Liat Fernández, David Friedman, Tom Heijligenberg, Rik Karlsson, Roger Kartun, Valery Klein, Adi Kreisberg, Racheli Kronenfeld, Gali Luijk, Bart Meijers, Pieter Navon, Roy Odeh, Majed Oved, Kfir Paz, Meital Pri-Or, Ester Rachmilevitch, Ronit Reisfeld, Sharon Schiff, Elad Simon, Einav Srugo, Isaac Stein, Michal Stubbs, Andrew Aik, & Bossink, W Collins, Laurence De Winter-De Groot, Karin Gottlieb, Tanya Hays, John Moore, & Oosterheert, Jan Sanjay, & Sankatsing, U Tom, & Van Houten, Chantal Wolfs, F Wouter De Waal, &
Source	PMC
abstract	Respiratory tract infections (RTI) are more commonly caused by viral pathogens in children than in adults. Surprisingly, little is known about antibiotic use in children as compared to adults with RTI. This prospective study aimed to determine antibiotic misuse in children and adults with RTI, using an expert panel reference standard, in order to prioritise the target age population for antibiotic stewardship interventions. We recruited children and adults who presented at the emergency department or were hospitalised with clinical presentation of RTI in The Netherlands and Israel. A panel of three experienced physicians adjudicated a reference standard diagnosis (i.e. bacterial or viral infection) for all the patients using all available clinical and laboratory information, including a 28-day follow-up assessment. The cohort included 284 children and 232 adults with RTI (median age, 1.3 years and 64.5 years, respectively). The proportion of viral infections was larger in children than in adults (209(74%) versus 89(38%), p < 0.001). In case of viral RTI, antibiotics were prescribed (i.e. overuse) less frequently in children than in adults (77/209 (37%) versus 74/89 (83%), p < 0.001). One (1%) child and three (2%) adults with bacterial infection were not treated with antibiotics (i.e. underuse); all were mild cases. This international, prospective study confirms major antibiotic overuse in patients with RTI. Viral infection is more common in children, but antibiotic overuse is more frequent in adults with viral RTI. Together, these findings support the need for effective interventions to decrease antibiotic overuse in RTI patients of all ages. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-018-03454-2) contains supplementary material, which is available to authorized users.
has issue date	2019-02-01(xsd:dateTime)
bibo:doi	10.1007/s10096-018-03454-2
bibo:pmid	30707378
has license	cc-by
sha1sum (hex)	c92206983f9523a96c8ea02210f70ee5640edd14
schema:url	https://doi.org/10.1007/s10096-018-03454-2
resource representing a document's title	Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment)
has PubMed Central identifier	PMC6394715
has PubMed identifier	30707378
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:c92206983f9523a96c8ea02210f70ee5640edd14#body_text
is schema:about of	named entity 'MISUSE' named entity 'bacterial infection' named entity 'This' named entity 'RTI' named entity 'adults' named entity 'patients' named entity 'Israel' named entity 'Netherlands' named entity 'Treatment' named entity 'PROSPECTIVE' named entity 'TREATMENT' named entity 'CHILDREN' named entity 'PRESENTED' named entity 'ORDER' named entity 'VIRAL INFECTION' named entity 'ANTIBIOTICS' named entity 'ISRAEL' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'PANEL' named entity 'FREQUENTLY' named entity 'ANTIBIOTIC' named entity 'USING' named entity 'YEARS' named entity 'NEED FOR' named entity 'DETERMINE' named entity 'ADULTS' named entity 'PHYSICIANS' named entity 'FINDINGS' named entity 'SUPPORT' named entity 'STEWARDSHIP' named entity 'TO DECREASE' named entity 'BUT' named entity 'DIAGNOSIS' named entity 'EFFECTIVE INTERVENTIONS' named entity 'VIRAL PATHOGENS'

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