About: Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation
Creator	Weldon, Sinéad Taggart, Clifford Kidney, Joseph Lungarella, Giuseppe Guo-Parke, Hong Herr, Christian Linden, Dermot Puttur, Franz
Source	Medline; PMC
abstract	Chronic obstructive pulmonary disease (COPD) is the integrated form of chronic obstructive bronchitis and pulmonary emphysema, characterized by persistent small airway inflammation and progressive irreversible airflow limitation. COPD is characterized by acute pulmonary exacerbations and associated accelerated lung function decline, hospitalization, readmission and an increased risk of mortality, leading to huge social-economic burdens. Recent evidence suggests ~50% of COPD acute exacerbations are connected with a range of respiratory viral infections. Nevertheless, respiratory viral infections have been linked to the severity and frequency of exacerbations and virus-induced secondary bacterial infections often result in a synergistic decline of lung function and longer hospitalization. Here, we review current advances in understanding the cellular and molecular mechanisms underlying the pathogenesis of COPD and the increased susceptibility to virus-induced exacerbations and associated immune dysfunction in patients with COPD. The multiple immune regulators and inflammatory signaling pathways known to be involved in host-virus responses are discussed. As respiratory viruses primarily target airway epithelial cells, virus-induced inflammatory responses in airway epithelium are of particular focus. Targeting virus-induced inflammatory pathways in airway epithelial cells such as Toll like receptors (TLRs), interferons, inflammasomes, or direct blockade of virus entry and replication may represent attractive future therapeutic targets with improved efficacy. Elucidation of the cellular and molecular mechanisms of virus infections in COPD pathogenesis will undoubtedly facilitate the development of these potential novel therapies that may attenuate the relentless progression of this heterogeneous and complex disease and reduce morbidity and mortality.
has issue date	2020-06-16(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01205
bibo:pmid	32655557
has license	cc-by
sha1sum (hex)	c9323c9fd0c0c391062f41e4c1e6c13c69e4530c
schema:url	https://doi.org/10.3389/fimmu.2020.01205
resource representing a document's title	Mechanisms of Virus-Induced Airway Immunity Dysfunction in the Pathogenesis of COPD Disease, Progression, and Exacerbation
has PubMed Central identifier	PMC7325903
has PubMed identifier	32655557
schema:publication	Front Immunol
resource representing a document's body	covid:c9323c9fd0c0c391062f41e4c1e6c13c69e4530c#body_text
is schema:about of	named entity 'molecular mechanisms' named entity 'exacerbations' named entity 'integrated' named entity 'inflammatory' named entity 'susceptibility' named entity 'future' named entity 'pulmonary' named entity 'Immunity' named entity 'Disease' named entity 'Airway' named entity 'MORBIDITY AND MORTALITY' named entity 'ACUTE EXACERBATIONS' named entity 'FOCUS' named entity 'PULMONARY' named entity 'LEADING' named entity 'FORM' named entity 'HETEROGENEOUS' named entity 'INTEGRATED' named entity 'TARGET' named entity 'BLOCKADE' named entity 'RISK OF' named entity 'NOVEL' named entity 'PATIENTS' named entity 'INTERFERONS' named entity 'mortality' named entity 'respiratory' named entity 'therapies' named entity 'result' named entity 'progression' named entity 'burdens' named entity 'pulmonary emphysema' named entity 'multiple' named entity 'Toll' named entity 'secondary' named entity 'focus' named entity 'attractive' named entity 'linked' named entity 'replication' named entity 'cellular' named entity 'inflammatory' named entity 'COPD' named entity 'respiratory viral infections' named entity 'interferons' named entity 'epithelial cells' named entity 'acute exacerbations' named entity 'inflammation' named entity 'chronic obstructive bronchitis' named entity 'therapeutic targets' named entity 'Chronic obstructive pulmonary disease' named entity 'COPD' named entity 'virus' named entity 'inflammasomes' named entity 'COPD' named entity 'REVIEW Mechanisms' named entity 'Airway' named entity 'disease' named entity 'pyrin domain' named entity 'neutrophil' named entity 'CD8 +' named entity 'defense mechanisms' named entity 'secretion' named entity 'oxidative stress' named entity 'TLR' named entity 'TLR4' named entity 'Granulocyte-macrophage colony-stimulating factor' named entity 'TLR2' named entity 'lung function' named entity 'Latent viral infections' named entity 'cold-like symptoms' named entity 'inflammatory response' named entity 'alveolar' named entity 'chemokines' named entity 'inflammation' named entity 'IRF-3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software