About: Characterization and evolution of the coronavirus porcine epidemic diarrhoea virus HLJBY isolated in China

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About: Characterization and evolution of the coronavirus porcine epidemic diarrhoea virus HLJBY isolated in China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization and evolution of the coronavirus porcine epidemic diarrhoea virus HLJBY isolated in China
Creator	Wang, Xiaobo Huan, Changchao Liu, \| Gao, \| Xu, Weiyin Chen, Changhai Fu, Siyao Gao, Qingqing Pan, Haochun
Source	Medline; PMC
abstract	A strain of porcine epidemic diarrhoea virus (PEDV), namely HLJBY, was isolated in Heilongjiang province, China. To provide insight into the understanding of the phylogenetic and the current epidemiological status of PEDV, PEDV HLJBY was compared with CV777 and other PEDV strains deposited in the GenBank. The homology between the entire genomic nucleotide sequences of PEDV HLJBY and CV777 was 97.7%. The homology of M gene was the highest (99.0%). However, the homology of ORF3 gene was 97.7%, and protein of ORF3 was 90.1%. In addition, HLJBY showed the highest nucleotide identity (99.9%) with PEDV‐SX/China/2017 strain and lowest similarity (91.2%) to PEDV/Belgorod/dom/2008 strain. We analysed the changes in S gene and its protein of PEDV HLJBY with 65 historic PEDV strains. The highest nucleotide identity was 99.9% compared with PEDV‐SX/China/2017 strain, and the lowest nucleotide identity was 60.0% compared with PEDV/Belgorod/dom/2008 strain. The length of deduced amino acid sequences of S proteins varied from 1,372 to 1,390 amino acids (aa). Compared with most aa sequences of S proteins, HLJBY exhibited 5 aa deletions (position 55, 59–61, 144). Analysis and comparison of open reading frame 3 (ORF3) proteins between HLJBY strain and other PEDV strains were also focused in this study. We revealed that the length of deduced amino acid sequences of ORF3 proteins was 80–224 aa among tested strains and the identity of HLJBY ORF3 amino acids with other PEDV strains was 71.4%–98.9%. ORF3 protein of both HLJBY strain and PEDV‐SX/China/2017 strain consists of 91 aa, with 133 aa deletions at their C' end in relation to the other tested PEDV strains. The phylogenetic tree based on different proteins or genes resulted in different phylogenetic groups. For pathogenicity evaluation of PEDV HLJBY strain, colostrum deprivation piglets were challenged with PEDV HLJBY, and PEDV reference strain CV777 as a control, the results showed that animals challenged with either of these PEDV strains developed diarrhoea, and histopathological examination of small intestines of challenged animals showed acute viral enteritis with villous atrophy in either PEDV HLJBY‐P10 or PEDV CV777‐P8 inoculated piglets.
has issue date	2019-08-22(xsd:dateTime)
bibo:doi	10.1111/tbed.13321
bibo:pmid	31381232
has license	no-cc
sha1sum (hex)	c96437dbc71c012f13dc6ad5d418aa37fe854650
schema:url	https://doi.org/10.1111/tbed.13321
resource representing a document's title	Characterization and evolution of the coronavirus porcine epidemic diarrhoea virus HLJBY isolated in China
has PubMed Central identifier	PMC7168556
has PubMed identifier	31381232
schema:publication	Transbound Emerg Dis
resource representing a document's body	covid:c96437dbc71c012f13dc6ad5d418aa37fe854650#body_text
is schema:about of	named entity '2017' named entity 'length' named entity 'evaluation' named entity 'amino acid' named entity '2008' named entity 'phylogenetic tree' named entity 'length' named entity 'STUDY' named entity 'STRAIN' named entity 'UNDERSTANDING' named entity 'GENE' named entity 'ITS' named entity 'GENES' named entity 'VIRAL ENTERITIS' named entity 'EVALUATION' named entity 'GENBANK' named entity 'GROUPS' named entity 'GENOMIC' covid:arg/c96437dbc71c012f13dc6ad5d418aa37fe854650 named entity 'villous atrophy' named entity 'strain' named entity 'amino acid' named entity 'proteins' named entity 'focused' named entity 'strains' named entity 'piglets' named entity 'strains' named entity 'viral' named entity 'sequences' named entity 'nucleotide' named entity 'strain' named entity 'phylogenetic analysis' named entity 'China' named entity 'proteins' named entity 'deletions' named entity 'virus' named entity 'porcine epidemic diarrhoea' named entity 'villous atrophy' named entity 'phylogenetic groups' named entity 'open reading frame' named entity 'phylogenetic' named entity 'diarrhoea' named entity 'China' named entity 'pathogenicity' named entity 'PEDV' named entity 'nucleotide sequences' named entity 'amino acid sequences' named entity 'China' named entity 'current' named entity 'evolution' named entity 'UTR' named entity 'clone' named entity 'milk replacer' named entity 'nucleotides' named entity 'PED' named entity 'nucleotides' named entity 'protein' named entity 'nucleotide sequence' named entity 'RNA' named entity 'polyadenylated tail' named entity 'PEDV' named entity 'nonstructural proteins' named entity 'genome' named entity 'amino acid sequence identity' named entity 'nucleoprotein' named entity 'amino acid sequence identity' named entity 'PEDV' named entity 'United Kingdom' named entity 'genome' named entity 'PEDV' named entity 'small intestine' named entity 'nucleotide sequences' named entity 'protein'

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