About: SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria

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About: SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria
Creator	Sortica, Vinicius Cunha, Maristela Deise, Maria Guimarães, Luciano Hutz, Mara Kc, Ândrea Lindenau, Juliana Ohnishi, O Santos, Sidney Ventura, Ana
Source	PMC
abstract	AIM: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. PATIENTS & METHODS: Totally, 164 Plasmodium vivax malaria infected patients were included. Generalized estimating equations were performed to determine gene influences on parasitemia and/or gametocytemia clearance over treatment time. RESULTS: Significant interaction between SLCO2B1 genotypes and treatment over time for parasitemia clearance rate on day 2 were observed (p (FDR) = 0.002). SLCO1A2 and SLCO1B1 gene treatment over time interactions were associated with gametocytemia clearance rate (p (FDR) = 0.018 and p (FDR) = 0.024). ABCB1, ABCC4 and SLCO1B3 were not associated with treatment response. CONCLUSION: The present work presents the first pharmacogenetic report of an association between chloroquine/primaquine responses with OATP transporters.
has issue date	2017-10-04(xsd:dateTime)
bibo:doi	10.2217/pgs-2017-0077
bibo:pmid	28975866
has license	cc-by
sha1sum (hex)	c96493dba4114ef8aada61335317d936692c6f5e
schema:url	https://doi.org/10.2217/pgs-2017-0077
resource representing a document's title	SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria
has PubMed Central identifier	PMC7099631
has PubMed identifier	28975866
schema:publication	Pharmacogenomics
resource representing a document's body	covid:c96493dba4114ef8aada61335317d936692c6f5e#body_text
is schema:about of	named entity 'pharmacogenetic' named entity 'influences' named entity 'chloroquine' named entity 'presents' named entity 'influences' named entity 'OATP' named entity 'SLCO2B1' named entity 'GENE POLYMORPHISMS' covid:arg/c96493dba4114ef8aada61335317d936692c6f5e named entity 'gene' named entity 'Results' named entity 'gene' named entity 'Generalized' named entity 'SLCO1B1' named entity 'SLCO1B3' named entity 'clearance rate' named entity 'genotypes' named entity 'chloroquine' named entity 'gene' named entity 'gene' named entity 'gene' named entity 'malaria' named entity 'primaquine' named entity 'malaria' named entity 'SLCO1A2' named entity 'SLCO1B1' named entity 'Plasmodium vivax' named entity 'polymorphisms' named entity 'clearance rate' named entity 'genotype' named entity 'pharmacogenetic' named entity 'drug resistance' named entity 'Parasitemia' named entity 'SLC' named entity 'Taqman' named entity 'translocation' named entity 'gametocytes' named entity 'polymorphism' named entity 'Declaration of Helsinki' named entity 'placebo' named entity 'infection' named entity 'proteinase' named entity 'P. vivax' named entity 'pharmacogenetics' named entity 'haplotype' named entity 'quinine' named entity 'Homozygous' named entity 'amphipathic' named entity 'ABCB1' named entity 'quinine' named entity 'polymorphisms' named entity 'genotypes' named entity 'link function' named entity 'ABCB1' named entity 'ABCC4' named entity 'SLCO2B1' named entity 'drug transport' named entity 'endemic' named entity 'red blood cell' named entity 'malaria' named entity 'linear function' named entity 'gametocytes' named entity 'standard treatment' named entity 'homozygotes' named entity 'Applied Biosystems' named entity 'p-value' named entity 'P. vivax' named entity 'drug transporters' named entity 'chloroquine' named entity 'SNP' named entity 'IEC' named entity 'Hardy-Weinberg'

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