About: Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection

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About: Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection
Creator	Wu, Ying Cheng, Anchun Wang, Mingshu Chen, Shun Jia, Renyong Chen, Xiaoyue Liu, Mafeng Sun, Kunfeng Sun, Lipei Wang, Anqi Yang, Qiao Zhu, Dekang
Source	Medline; PMC
abstract	As interferon-stimulated genes (ISGs), interferon-inducible transmembrane proteins 1 and 3 (IFITM1 and IFITM3) can effectively inhibit the replication of multiple viruses. Here, goose IFITM1 and IFITM3 were cloned and identified for the first time. The two proteins share the same topological structure and several important sites critical for the antiviral functions in other species are conserved in the goose. Goose IFITM1 and IFITM3 are most closely related to their respective orthologs in ducks; these proteins exhibited high mRNA transcript levels in immune-related tissues, including the thymus, bursa of Fabricius, and Harderian gland, compared to other tissues. Moreover, goose IFITM1 was highly constitutively expressed in gastrointestinal tract tissues, while goose IFITM3 was expressed in respiratory organs. Furthermore, goose IFITM3 was activated in goose peripheral blood mononuclear cells (PBMCs) infected with Tembusu virus (TMUV) or treated with Toll-like receptors (TLRs) agonists, while only the R848 and Poly (I:C) agonists induced significant upregulation of goose IFITM1. Furthermore, goose IFITM1 and IFITM3 were upregulated in the sampled tissues, to some extent, after TMUV infection. Notably, significant upregulation of goose IFITM1 and IFITM3 was detected in the cecum and cecal tonsil, where TMUV was primarily distributed. These data provide new insights into the immune effectors in geese and promote our understanding of the role of IFITM1 and IFITM3 in the defense against TMUV.
has issue date	2017-03-13(xsd:dateTime)
bibo:doi	10.1155/2017/5149062
bibo:pmid	28386554
has license	cc-by
sha1sum (hex)	c96d197b59d78b7d5dba68fb9a4e5ef67bd066d1
schema:url	https://doi.org/10.1155/2017/5149062
resource representing a document's title	Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection
has PubMed Central identifier	PMC5366768
has PubMed identifier	28386554
schema:publication	Biomed Res Int
resource representing a document's body	covid:c96d197b59d78b7d5dba68fb9a4e5ef67bd066d1#body_text
is schema:about of	named entity 'GENE STRUCTURE' named entity 'IFITM1' named entity 'CECAL TONSIL' named entity 'BURSA OF FABRICIUS' named entity 'HIGH' named entity 'INDUCIBLE' named entity 'THYMUS' named entity 'SPECIES' named entity 'DEFENSE' named entity 'SIGNIFICANT' named entity 'TOLL-LIKE RECEPTORS' named entity 'UPREGULATION' named entity 'SITES' named entity 'THESE' named entity 'EXPRESSED' named entity 'OUR' named entity 'TIME' named entity 'GOOSE' named entity 'CRITICAL' named entity 'PROTEINS' named entity 'ANTIVIRAL' named entity 'RESPIRATORY' named entity 'CONSERVED' named entity 'INSIGHTS' named entity 'REPLICATION' named entity 'POLY' named entity 'TRANSCRIPT' named entity 'COMPARED' named entity 'SAMPLED' named entity 'TO SOME EXTENT' named entity 'PROVIDE' named entity 'INTERFERON' named entity 'TRANSMEMBRANE PROTEINS' named entity 'FUNCTIONS' named entity 'DETECTED' named entity 'INFECTION' named entity 'TREATED WITH' named entity 'DATA' named entity 'MRNA' named entity 'UNDERSTANDING' named entity 'WHERE' named entity '28I' named entity 'IFITM1' named entity 'EXPRESSION' named entity 'IDENTIFICATION' named entity 'PROMOTE' named entity 'VIRUSES' named entity 'INCLUDING' named entity 'IFITM3' named entity 'TISSUES' named entity 'CLONED' named entity 'INDUCED' named entity 'UPREGULATED' named entity 'HARDERIAN GLAND' named entity 'IMPORTANT' named entity 'IFITM3' named entity 'IDENTIFIED' named entity 'GOOSE' named entity 'TEMBUSU VIRUS' named entity 'VIRUS INFECTION' named entity 'IMMUNE' named entity 'THEIR' named entity 'ACTIVATED' named entity 'STIMULATED' named entity 'MULTIPLE' named entity 'GEESE' named entity 'IMMUNE' named entity 'AGONISTS' named entity 'LEVELS' named entity 'GENES'

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