About: Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses
Creator	Gil, Laura Bueno, Renata Fernandes, Rafaela Freire, Marjorie Godoy, Andre Oliva, Glaucius
Source	Medline; PMC
abstract	Single-stranded positive RNA ((+) ssRNA) viruses include several important human pathogens. Some members are responsible for large outbreaks, such as Zika virus, West Nile virus, SARS-CoV, and SARS-CoV-2, while others are endemic, causing an enormous global health burden. Since vaccines or specific treatments are not available for most viral infections, the discovery of direct-acting antivirals (DAA) is an urgent need. Still, the low-throughput nature of and biosafety concerns related to traditional antiviral assays hinders the discovery of new inhibitors. With the advances of reverse genetics, reporter replicon systems have become an alternative tool for the screening of DAAs. Herein, we review decades of the use of (+) ssRNA viruses replicon systems for the discovery of antiviral agents. We summarize different strategies used to develop those systems, as well as highlight some of the most promising inhibitors identified by the method. Despite the genetic alterations introduced, reporter replicons have been shown to be reliable systems for screening and identification of viral replication inhibitors and, therefore, an important tool for the discovery of new DAAs.
has issue date	2020-05-30(xsd:dateTime)
bibo:doi	10.3390/v12060598
bibo:pmid	32486283
has license	cc-by
sha1sum (hex)	ca342b4458a9e6c05678b5cfa77ae2b0128d14e3
schema:url	https://doi.org/10.3390/v12060598
resource representing a document's title	Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses
has PubMed Central identifier	PMC7354593
has PubMed identifier	32486283
schema:publication	Viruses
resource representing a document's body	covid:ca342b4458a9e6c05678b5cfa77ae2b0128d14e3#body_text
is schema:about of	named entity 'SARS-COV-2' named entity 'USE OF' named entity 'STRATEGIES' named entity 'VACCINES' named entity 'VIRAL REPLICATION' named entity 'RNA' named entity 'INHIBITORS' named entity 'IDENTIFIED BY' named entity 'BURDEN' named entity 'glycoprotein' named entity '293T cells' named entity 'azauridine' named entity 'replicon' named entity 'Viruses' named entity 'genotype' named entity 'replicons' named entity 'small-molecule' named entity 'Daclatasvir' named entity 'DENV' named entity 'NS3' named entity 'Alphavirus' named entity 'ivermectin' named entity 'replicon' named entity 'viral infections' named entity 'reverse genetics' named entity 'SARS-CoV-2' named entity 'DAAs' named entity 'antiviral' named entity 'RNA' named entity 'DAAs' named entity 'viruses' named entity 'viruses' named entity 'antiviral' named entity 'structural proteins' named entity 'NS3' named entity 'Coxsackievirus B3' named entity 'viral replication' named entity 'IRES' named entity 'green fluorescent protein' named entity 'Silymarin' named entity 'structural proteins' named entity 'host cell' named entity 'Alphavirus infections' named entity 'primaquine' named entity 'transfected' named entity 'GFP' named entity 'cell-based' named entity 'NS4A' named entity 'NS5B' named entity 'viral structural proteins' named entity 'genotypic' named entity 'interferon' named entity 'high-throughput' named entity 'EGFP' named entity 'mosquito' named entity 'RdRp' named entity 'non-enveloped' named entity 'NS2' named entity 'infection' named entity 'Flavivirus' named entity 'genome' named entity 'bacteriophage' named entity 'acute hepatitis' named entity 'receptor tyrosine kinase' named entity 'Poliovirus' named entity 'RNA replication' named entity 'HEV' named entity 'NS5A' named entity 'Virions' named entity 'ZIKV' named entity 'replicon' named entity 'NS4A' named entity 'gene' named entity 'poliomyelitis' named entity 'transfect' named entity 'Amodiaquine'

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