About: Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species
Creator	N I K O L I N, O Xi M E N,
topic	covid:ca462250f60c87d1fa86c46f1bbab1c99f065304#this
Source	PMC
abstract	Was the 1993/1994 fatal canine distemper virus (CDV) epidemic in lions and spotted hyaenas in the Serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? We examine this question using sequence data from 13 ‘Serengeti’ strains including five complete genomes obtained between 1993 and 2011. Phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other than to those from domestic or wild canids. All noncanid ‘Serengeti’ strains during the epidemic encoded: (1) one novel substitution G134S in the CDV‐V protein; and (2) the rare amino acid combination 519I/549H at two sites under positive selection in the region of the CDV‐H protein that binds to SLAM (CD 150) host cell receptors. Worldwide, only a few noncanid strains in the America II lineage encode CDV‐H 519I/549H. All canid ‘Serengeti’ strains during the epidemic coded CDV‐V 134G, and CDV‐H 519R/549Y, or 519R/549H. A functional assay of cell entry revealed the highest performance by CDV‐H proteins encoding 519I/549H in cells expressing lion SLAM receptors, and the highest performance by proteins encoding 519R/549Y, typical of dog strains worldwide, in cells expressing dog SLAM receptors. Our findings are consistent with an epidemic in lions and hyaenas caused by CDV variants better adapted to noncanids than canids, but not with the recent spillover of a dog strain. Our study reveals a greater complexity of CDV molecular epidemiology in multihost environments than previously thought.
has issue date	2016-12-07(xsd:dateTime)
bibo:doi	10.1111/mec.13902
bibo:pmid	27928865
has license	no-cc
sha1sum (hex)	ca462250f60c87d1fa86c46f1bbab1c99f065304
schema:url	https://doi.org/10.1111/mec.13902
resource representing a document's title	Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species
has PubMed Central identifier	PMC7168383
has PubMed identifier	27928865
schema:publication	Mol Ecol
resource representing a document's body	covid:ca462250f60c87d1fa86c46f1bbab1c99f065304#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/ca462250f60c87d1fa86c46f1bbab1c99f065304
is schema:about of	named entity 'dog' named entity 'lions' named entity 'adapted' named entity 'CDV' named entity 'cells' named entity 'domestic dog' named entity 'strains' named entity 'protein' named entity 'rare' named entity 'wild' named entity 'adaptation' named entity 'A L' named entity 'CODED' named entity 'GREATER' named entity 'SLAM' named entity 'OTHER THAN' named entity 'CELL' named entity 'environments' named entity 'consistent' named entity 'performance' named entity 'reveals' named entity 'CDV' named entity 'data' named entity 'encoding' named entity 'fatal' named entity 'canid' named entity 'clade' named entity 'histidine' named entity 'Neovison vison' named entity 'C-terminus' named entity 'SNP' named entity 'syncytium' named entity 'glycine' named entity 'CDV' named entity 'coded' named entity 'lions' named entity 'strains' named entity 'Worldwide' named entity 'dog' named entity 'cell entry' named entity 'CDV' named entity 'CDV' named entity 'epidemic' named entity 'positive selection' named entity 'host cell' named entity 'amino acid' named entity 'canine distemper virus' named entity 'CDV' named entity 'CDV' named entity 'virulent' named entity 'Serengeti' named entity 'epidemic' named entity 'carnivore' named entity 'Serengeti' named entity 'gene sequences' named entity 'positive selection' named entity 'domestic dogs' named entity 'PCR' named entity 'canid' named entity 'Mustelidae' named entity 'canid' named entity 'MNN' named entity 'canids' named entity 'CDV' named entity 'domestic dog' named entity 'dog' named entity 'anaesthetized' named entity 'domestic cat' named entity 'bat-eared fox' named entity 'CDV' named entity 'CDV' named entity 'Serengeti' named entity '5.1' named entity 'CDV' named entity 'America II' named entity 'cell type' named entity 'arginine' named entity 'nuclei'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software