About: Three unique Sendai virus antigenic peptides screened from nucleocapsid protein by overlapping peptide array

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About: Three unique Sendai virus antigenic peptides screened from nucleocapsid protein by overlapping peptide array Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Three unique Sendai virus antigenic peptides screened from nucleocapsid protein by overlapping peptide array
Creator	Qin, Chuan Wei, Qiang Li, Yuhan Tong, Wei Xiang, Zhiguang
Source	Elsevier; Medline; PMC
abstract	Abstract Sendai virus (SeV) is strictly monitored in laboratory rodents. Currently, complete virions have been used as antigens in SeV serological tests. However, the complexity of SeV virion antigen limits the accuracy of the diagnostic method. In the current study, complete SeV virion antigen was separated on SDS-PAGE and analyzed, with nucleocapsid protein (NP) showing predominant antigenicity. A peptide array containing overlapping 14-mer peptides covering the entire NP was developed. The array used SeV positive serum and resulted in four antigenic linear peptides being identified, which were located in the carboxyl-terminus of NP. The four peptides were coated on ELISA plates and tested with SeV positive and SeV negative sera, and the antigenicity of three peptides, NP413–428, NP473–490 and NP507–524, was confirmed. Mixture of the three peptides showed comparable sensitivity and better specificity in clinical rat sera ELISA tests compared with complete SeV virion antigen. In conclusion, the three peptides, NP413–428, NP473–490 and NP507–524, would be good candidates as linear antigens for SeV detection.
has issue date	2013-11-30(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2013.06.011
bibo:pmid	23811230
has license	els-covid
sha1sum (hex)	ca4a51007d5391daa4fbfd956fa5ec21f3839052
schema:url	https://doi.org/10.1016/j.jviromet.2013.06.011
resource representing a document's title	Three unique Sendai virus antigenic peptides screened from nucleocapsid protein by overlapping peptide array
has PubMed Central identifier	PMC7113644
has PubMed identifier	23811230
schema:publication	Journal of Virological Methods
resource representing a document's body	covid:ca4a51007d5391daa4fbfd956fa5ec21f3839052#body_text
is schema:about of	named entity 'NUCLEOCAPSID PROTEIN' named entity 'SeV' named entity 'SeV' named entity 'SeV' named entity 'complete' named entity 'antigenicity' named entity 'UNIQUE' named entity 'PEPTIDE ARRAY' named entity 'CONFIRMED' named entity 'USED' named entity 'COVERING' named entity 'BETTER' named entity 'GOOD' named entity 'LINEAR' named entity 'SEPARATED' named entity 'TESTS' named entity 'PROTEIN ' named entity 'RAT' named entity 'MIXTURE' named entity 'PREDOMINANT' named entity 'VIRIONS' named entity 'CURRENT' named entity 'ANTIGEN' named entity 'COMPLETE' named entity 'SEV' named entity 'MER' named entity 'SEROLOGICAL TESTS' named entity 'HAVE' named entity 'PEPTIDES' named entity 'STUDY' named entity 'ANTIGENICITY' named entity 'ACCURACY' named entity 'CONTAINING' named entity 'TERMINUS' covid:arg/ca4a51007d5391daa4fbfd956fa5ec21f3839052 named entity 'PEPTIDE ARRAY' named entity 'RODENTS' named entity 'MONITORED' named entity 'LIMITS' named entity 'LOCATED IN' named entity 'LABORATORY' named entity 'BEING' named entity 'SPECIFICITY' named entity 'CLINICAL' named entity 'SENDAI VIRUS' named entity 'SERA' named entity 'COMPARED' named entity 'DETECTION' named entity '428' named entity 'IDENTIFIED' named entity 'NEGATIVE' named entity 'POSITIVE' named entity 'SENSITIVITY' named entity 'SDS-PAGE' named entity 'VIRION' named entity 'ARRAY' named entity 'SENDAI VIRUS' named entity 'PROTEIN ' named entity 'SERUM' named entity 'ANALYZED' named entity 'ANTIGENS' named entity 'COATED' named entity 'ENTIRE' named entity 'PEPTIDES' named entity 'CURRENTLY' named entity 'TESTED' named entity 'COMPLEXITY' named entity 'DIAGNOSTIC METHOD' named entity '524' named entity 'OVERLAPPING' named entity 'CONCLUSION' named entity 'OVERLAPPING' named entity 'ELISA' named entity 'CARBOXYL' named entity 'NUCLEOCAPSID PROTEIN' named entity 'PLATES' named entity 'carboxyl-terminus'

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