About: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent

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About: The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent
Creator	Pöhlmann, Stefan Marzi, Andrea Hoffmann, Markus Berger, Elisabeth González Hernández, Mariana
source	Medline; PMC
abstract	Ebola and marburgviruses, members of the family Filoviridae, can cause severe hemorrhagic fever in humans. The ongoing Ebola virus (EBOV) disease epidemic in Western Africa claimed more than 11,300 lives and was associated with secondary cases outside Africa, demonstrating that filoviruses pose a global health threat. Bats constitute an important natural reservoir of filoviruses, including viruses of the recently identified Cuevavirus genus within the Filoviridae family. However, the interactions of filoviruses with bat cells are incompletely understood. Here, we investigated whether filoviruses employ different strategies to enter human and bat cells. For this, we examined host cell entry driven by glycoproteins (GP) from all filovirus species into cell lines of human and fruit bat origin. We show that all GPs were able to mediate entry into human and most fruit bat cell lines with roughly comparable efficiency. In contrast, the efficiency of entry into the cell line EidNi/41 derived from a straw-colored fruit bat varied markedly between the GPs of different filovirus species. Furthermore, inhibition studies demonstrated that filoviruses employ the same host cell factors for entry into human, non-human primate and fruit bat cell lines, including cysteine proteases, two pore channels and NPC1 (Niemann-Pick C1 molecule). Finally, processing of GP by furin and the presence of the mucin-like domain in GP were dispensable for entry into both human and bat cell lines. Collectively, these results show that filoviruses rely on the same host cell factors for entry into human and fruit bat cells, although the efficiency of the usage of these factors might differ between filovirus species.
has issue date	2016-02-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0149651
bibo:pmid	26901159
has license	cc-by
sha1sum (hex)	ca96f361ba8d99dedbd1421fe735d230e86f7797
schema:url	https://doi.org/10.1371/journal.pone.0149651
resource representing a document's title	The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent
has PubMed Central identifier	PMC4762945
has PubMed identifier	26901159
schema:publication	PLoS One
resource representing a document's body	covid:ca96f361ba8d99dedbd1421fe735d230e86f7797#body_text
is schema:about of	covid:arg/ca96f361ba8d99dedbd1421fe735d230e86f7797 named entity 'cell lines' named entity 'filoviruses' named entity 'cysteine proteases' named entity 'hemorrhagic fever' named entity 'Filoviridae' named entity 'viruses' named entity 'fruit bat' named entity 'disease epidemic' named entity 'filoviruses' named entity 'Western Africa' named entity 'host cell' named entity 'Filoviridae' named entity 'bat' named entity 'filoviruses' named entity 'cell lines' named entity 'Glycoproteins' named entity 'Egyptian fruit bat' named entity 'phylogenetic tree' named entity 'epidemic' named entity 'restriction sites' named entity 'camostat' named entity 'filovirus' named entity 'Thermo Scientific' named entity 'cell lines' named entity 'filovirus' named entity 'fruit bats' named entity 'filoviruses' named entity 'cell lines' named entity 'fruit bat' named entity 'Sub-Saharan Africa' named entity 'Mexico' named entity 'Ebola virus disease' named entity 'PCR' named entity '0.01' named entity 'TAFV' named entity 'RESTV' named entity 'filovirus' named entity 'cell line' named entity 'TIM-1' named entity 'SUDV' named entity 'mesylate' named entity 'bafilomycin A1' named entity 'cysteine protease' named entity 'proteases' named entity 'entry process' named entity '11 October 2015' named entity 'cell lines' named entity 'cell lines' named entity 'DAAD' named entity 'fruit bat' named entity 'Zoonosis' named entity 'cynomolgus macaques' named entity '293T cells' named entity 'Ravn virus' named entity 'natural reservoir' named entity 'filovirus' named entity 'mammalian cells' named entity 'diluent' named entity 'Filoviridae' named entity 'bat' named entity 'two-pore channels' named entity 'glycoproteins' named entity 'fruit bat' named entity 'NPC1' named entity 'filovirus' named entity 'infectivity' named entity 'transmitted to humans' named entity 'filoviruses' named entity 'bat' named entity 'furin' named entity 'NHP' named entity 'proprotein convertases' named entity 'bat' named entity 'filovirus' named entity 'cell lines' named entity 'cell lines'

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