About: Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing()

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing()
Creator	Casas, Inmaculada Calvo, Cristina Pozo, Francisco Aguado, Isabel Calderon, Ana Campelo, Olga Díaz-Martinez, Eloisa Fernandez-Arroyo, Rosa Fernandez-Rincón, Adelaida Muñóz-Gonzalez, Luisa Olivas, Antonio Ruiz-Chercoles, Esther Albañil, Rosa García-García, Luz Pediatr, An Barc,
Source	PMC
abstract	INTRODUCTION: It is known that infants with viral respiratory infections severe enough to require hospital admission have a high risk of developing recurrent wheezing. Few data have been published on unselected populations. The main aim of this study was to analyse symptomatic and asymptomatic respiratory viral infections during the first year of life in a cohort of infants, recruited at birth, and the development of recurrent wheezing. PATIENTS AND METHODS: A total of 302 newborns were recruited. A nasopharyngeal aspirate was taken when the patients had a respiratory infection, as well as in the visits for vaccination at 2, 4, 6, and 12 months. RT-nested PCR assays were performed to detect 16 viruses. RESULTS: A total of 1293 samples were analysed (1005 healthy controls and 288 respiratory infections). Samples taken during routine check-ups were positive in 30.8% of cases, while those with respiratory infection were positive in 77.8%, P < .001 (OR: 3, 95% CI: 2.4–3.8). A total of 239 (79%) infants had at least 1 positive respiratory viral infection detected. The most frequent virus (71%) was rhinovirus (RV). Recurrent wheezing was found in 27 (11%) children during their first year of life (1.2 episodes, SD 2.9). Recurrent wheezing was present in 58.3% of patients admitted to hospital during their first viral infection, vs. 8.6% of infants when the first infection was mild or who had asymptomatic viral detection, P < .001 (OR: 2.18; 95% CI: 1.05–4.5). CONCLUSIONS: In our series, severe respiratory infections leading to hospitalisation in the first months of life are risk factors for developing wheezing, but not in the case of mild RV infections.
has issue date	2017-07-06(xsd:dateTime)
bibo:doi	10.1016/j.anpede.2016.08.008
has license	no-cc
sha1sum (hex)	cb553fd4acc28d350c10b9b0f8555fc60f952803
schema:url	https://doi.org/10.1016/j.anpede.2016.08.008
resource representing a document's title	Respiratory viral infections in a cohort of children during the first year of life and their role in the development of wheezing()
has PubMed Central identifier	PMC7146761
schema:publication	An Pediatr (Engl Ed)
resource representing a document's body	covid:cb553fd4acc28d350c10b9b0f8555fc60f952803#body_text
is schema:about of	named entity 'DEVELOPMENT' named entity 'aspirate' named entity 'viral' named entity 'patients' named entity 'wheezing' named entity 'life' named entity 'RECURRENT' named entity 'THEIR' named entity 'TOTAL' named entity 'RESPIRATORY INFECTION' named entity 'PUBLISHED' named entity 'DATA' named entity 'HIGH RISK OF' named entity 'VIRUSES' named entity 'DEVELOPMENT' named entity 'AT BIRTH' named entity 'ROLE' named entity 'METHODS' named entity 'POPULATIONS' named entity 'TAKEN' named entity 'VIRAL' named entity 'VIRAL INFECTIONS' named entity 'NEWBORNS' named entity 'SEVERE' named entity 'YEAR' named entity 'COHORT' named entity 'KNOWN' named entity 'ASYMPTOMATIC' named entity 'RECURRENT' named entity 'RESPIRATORY' named entity 'VACCINATION' named entity 'LIFE' named entity 'HAVE' named entity '12 MONTHS' named entity 'MAIN' named entity 'YEAR' named entity 'STUDY' named entity 'ENOUGH' named entity 'WHEEZING' named entity 'DEVELOPING' named entity 'WHEEZING' named entity 'WORKING GROUP' named entity 'CHILDREN' named entity 'VIRAL INFECTIONS' named entity 'COHORT' named entity 'AIM' named entity 'NASOPHARYNGEAL ASPIRATE' named entity 'INFANTS' named entity 'VISITS' named entity 'HOSPITAL ADMISSION' named entity 'PERFORMED' named entity 'INTRODUCTION' named entity 'PATIENTS' named entity 'SYMPTOMATIC' named entity 'TO DETECT' named entity 'NESTED PCR ' named entity 'RESPIRATORY' named entity 'LIFE' named entity 'RESPIRATORY INFECTIONS' named entity 'asymptomatic' named entity 'published' named entity 'PCR' named entity 'aim' named entity 'Wheezing' named entity 'Working Group' named entity 'respiratory infection' named entity 'nasopharyngeal aspirate' named entity 'asymptomatic'

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