About: Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis

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About: Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis
Creator	Ramakrishna, Chandran Bergmann, Cornelia Macklin, Wendy Stohlman, Stephen Malone, Karen
topic	covid:cb6bc03f06dead8e79159e79f46ae11cfe218aff#this
source	Medline; PMC
abstract	Glia exhibit differential susceptibility to CD8 T cell mediated effector mechanisms during neurotropic coronavirus infection. In contrast to microglia, oligodendroglia are resistant to CD8 T cell perforin‐mediated viral control in the absence of IFNγ. Kinetic induction of MHC Class I expression by microglia and oligodendroglia in vivo was thus analyzed to assess responses to distinct inflammatory signals. Flow cytometry demonstrated delayed Class I surface expression by oligodendroglia compared with microglia. Distinct kinetics of Class I protein upregulation correlated with cell type specific transcription patterns of genes encoding Class I heavy chains and antigen processing components. Microglia isolated from naïve mice expressed high levels of these mRNAs, whereas they were near detection limits in oligodendroglia; nevertheless, Class I protein was undetectable on both cell types. Infection induced modest mRNA increases in microglia, but dramatic transcriptional upregulation in oligodendroglia coincident with IFNα or IFNγ mRNA increases in infected tissue. Ultimately mRNAs reached similar levels in both cell types at their respective time points of maximal Class I expression. Expression of Class I on microglia, but not oligodendroglia, in infected IFNγ deficient mice supported distinct IFN requirements for Class I presentation. These data suggest an innate immune preparedness of microglia to present antigen and engage CD8 T cells early following infection. The delayed, yet robust, IFNγ dependent capacity of oligodendroglia to express Class I suggests strict control of immune interactions to avoid CD8 T cell recognition and potential presentation of autoantigen to preserve myelin maintenance. © 2008 Wiley‐Liss, Inc.
has issue date	2008-01-18(xsd:dateTime)
bibo:doi	10.1002/glia.20625
bibo:pmid	18205173
has license	no-cc
sha1sum (hex)	cb6bc03f06dead8e79159e79f46ae11cfe218aff
schema:url	https://doi.org/10.1002/glia.20625
resource representing a document's title	Induction of class I antigen processing components in oligodendroglia and microglia during viral encephalomyelitis
has PubMed Central identifier	PMC7165990
has PubMed identifier	18205173
schema:publication	Glia
resource representing a document's body	covid:cb6bc03f06dead8e79159e79f46ae11cfe218aff#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/cb6bc03f06dead8e79159e79f46ae11cfe218aff https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/cb6bc03f06dead8e79159e79f46ae11cfe218aff
is schema:about of	named entity 'coincident' named entity 'Class I' named entity 'IFNg' named entity 'undetectable' named entity 'microglia' named entity 'expression' named entity 'LEVELS' named entity 'SURFACE' named entity 'CAPACITY' named entity 'CD8' named entity 'DEPENDENT' covid:arg/cb6bc03f06dead8e79159e79f46ae11cfe218aff named entity 'oligodendroglia' named entity 'effector' named entity 'IFN' named entity 'cell types' named entity 'myelin' named entity 'detection' named entity 'encoding' named entity 'preserve' named entity 'microglia' named entity 'patterns' named entity 'expression' named entity 'viral' named entity 'oligodendroglia' named entity 'protein' named entity 'Glia' named entity 'infection' named entity 'myelin' named entity 'oligodendroglia' named entity 'present antigen' named entity 'Microglia' named entity 'mRNA' named entity 'oligodendroglia' named entity 'microglia' named entity 'deficient mice' named entity 'effector' named entity 'microglia' named entity 'antigen processing' named entity 'microglia' named entity 'mRNAs' named entity 'Microglia' named entity 'microglia' named entity 'Infection' named entity 'infection' named entity 'heavy chains' named entity 'microglia' named entity 'upregulation' named entity 'Antigen Processing' named entity 'oligodendroglia' named entity 'mice' named entity 'Encephalomyelitis' named entity 'inflammatory' named entity 'microglia' named entity 'oligodendroglia' named entity 'mRNA' named entity 'CD8 T cell' named entity 'mRNAs' named entity 'cell type' named entity 'CD8 T cell' named entity 'innate immune' named entity 'engage' named entity 'coronavirus' named entity 'mRNAs' named entity 'microglia' named entity 'Oligodendroglia' named entity 'DELAYED' named entity 'MEDIATED' named entity 'SPECIFIC' named entity 'COINCIDENT' named entity 'ANALYZED' named entity 'maximal Class' named entity 'IFNg' named entity 'CD8 T cell'

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