About: Nrf2 Activator PB125(®) as a Potential Therapeutic Agent against COVID-19

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About: Nrf2 Activator PB125(®) as a Potential Therapeutic Agent against COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nrf2 Activator PB125(®) as a Potential Therapeutic Agent against COVID-19
Creator	Gao, Bifeng Cota-Gomez, Adela Geraci, Kara Hybertson, Brooks Mccord, Joe
Source	Medline; PMC; WHO
abstract	Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 activity declines with age, making the elderly more susceptible to oxidative stress-mediated diseases, which include type 2 diabetes, chronic inflammation, and viral infections. Published evidence suggests that Nrf2 activity may regulate important mechanisms affecting viral susceptibility and replication. We examined gene expression levels by GeneChip microarray and by RNA-seq assays. We found that the potent Nrf2-activating composition PB125(®) downregulates ACE2 and TMPRSS2 mRNA expression in human liver-derived HepG2 cells. ACE2 is a surface receptor and TMPRSS2 activates the spike protein for SARS-CoV-2 entry into host cells. Furthermore, in endotoxin-stimulated primary human pulmonary artery endothelial cells, we report the marked downregulation by PB125 of 36 genes encoding cytokines. These include IL-1-beta, IL-6, TNF-α, the cell adhesion molecules ICAM-1, VCAM-1, and E-selectin, and a group of IFN-γ-induced genes. Many of these cytokines have been specifically identified in the “cytokine storm” observed in fatal cases of COVID-19, suggesting that Nrf2 activation may significantly decrease the intensity of the storm.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.3390/antiox9060518
bibo:pmid	32545518
has license	cc-by
sha1sum (hex)	cbf94a39e285133ee4149e4c773a8d347d01e9f0
schema:url	https://doi.org/10.3390/antiox9060518
resource representing a document's title	Nrf2 Activator PB125(®) as a Potential Therapeutic Agent against COVID-19
has PubMed Central identifier	PMC7346195
has PubMed identifier	32545518
schema:publication	Antioxidants (Basel)
resource representing a document's body	covid:cbf94a39e285133ee4149e4c773a8d347d01e9f0#body_text
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