About: miR-1975 serves as an indicator of clinical severity upon influenza infection

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About: miR-1975 serves as an indicator of clinical severity upon influenza infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	miR-1975 serves as an indicator of clinical severity upon influenza infection
Creator	Lai, Michael Su, Wen-Chi Chen, Yi-Chun Chen, Hui-Chen Ho, Chia-Yin Ho, Yen Liu, Yuag-Meng Meng, & Yu, Wen-Ya
Source	PMC
abstract	Emerging evidence highlights the role of non-coding small RNAs in host-influenza interaction. We have identified a Y RNA-derived small RNA, miR-1975, which is upregulated upon influenza A virus infection in A549 cells. The aim of this study is to investigate whether miR-1975 serves as an indicator of clinical severity upon influenza infection. We investigate the abundance of miR-1975 in sera from clinical patients and its correlation with hypoxemia status. We quantified its amounts in sera from influenza virus-infected patients and healthy volunteers by means of stem-loop RT-PCR. Median values of miR-1975 were significantly higher in influenza virus-infected patients, especially in hypoxemic patients. miR-1975 levels at the acute stage of the disease were highly correlated with the fraction of inspired oxygen used by the patients and total ventilator days. Receiver operator characteristic curve analysis revealed that miR-1975 levels in combination with days of fever before presenting to hospital had significant predictive value for hypoxemia and respiratory failure for patients infected with influenza virus. Our results reveal that circulating miR-1975 has great potential to serve as a biomarker for predicting prognosis in patients infected with influenza virus.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1007/s10096-020-04008-1
has license	no-cc
sha1sum (hex)	cc333be2c2b4510da04c9432647f481686b60808
schema:url	https://doi.org/10.1007/s10096-020-04008-1
resource representing a document's title	miR-1975 serves as an indicator of clinical severity upon influenza infection
has PubMed Central identifier	PMC7437959
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:cc333be2c2b4510da04c9432647f481686b60808#body_text
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