About: Analysis of the spike, ORF3, and nucleocapsid genes of porcine epidemic diarrhea virus circulating on Thai swine farms, 2011

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About: Analysis of the spike, ORF3, and nucleocapsid genes of porcine epidemic diarrhea virus circulating on Thai swine farms, 2011–2016 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of the spike, ORF3, and nucleocapsid genes of porcine epidemic diarrhea virus circulating on Thai swine farms, 2011–2016
Creator	Amonsin, Alongkorn Assavacheep, Pornchalit Luengyosluechakul, Supol Phupolphan, Cherdpong Poovorawan, Yong Theamboonlers, Apiradee Tuanthap, Supansa Vongpunsawad, Sompong Wattanaphansak, Suphot Duang-In, Ausanee
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV) outbreaks on pig farms have caused significant economic loss in the swine industry since it was first reported in Thailand a decade ago. Anecdotal evidence suggests that PEDV is now endemic in this region, therefore genome information of circulating PEDV is important for molecular surveillance and evaluation of potential benefits of field vaccination. Here, we characterized PEDV infection on commercial Thai swine farms by screening 769 samples of feces and small intestinal contents from pigs with diarrhea between 2011 and 2016. Using reverse-transcription polymerase chain reaction targeting the spike (S) gene, 153 PEDV-positive samples were further subjected to analysis of the open reading frame 3 and nucleocapsid (N) genes. Comparison of 95 samples in which nucleotide sequencing was successfully obtained for all three genes revealed evolutionary diversity among the Thai PEDV strains. Phylogenetic analyses suggest that although some Thai strains changed little from years past, others resembled more closely to the recent strains reported in China. Interestingly, eight Thai PEDV strains possessed amino acid deletions in the N protein. The PEDV sequence divergence may be responsible for driving periodic outbreaks and continued persistence of PEDV on commercial swine farms. Our findings provide important insight into regional PEDV strains in circulation, which may assist future inclusions of suitable strains for future PEDV vaccines.
has issue date	2019-04-30(xsd:dateTime)
bibo:doi	10.7717/peerj.6843
bibo:pmid	31106060
has license	cc-by
sha1sum (hex)	cc8e81f5fd3efda044a42e965278d17c58bb4ea6
schema:url	https://doi.org/10.7717/peerj.6843
resource representing a document's title	Analysis of the spike, ORF3, and nucleocapsid genes of porcine epidemic diarrhea virus circulating on Thai swine farms, 2011–2016
has PubMed Central identifier	PMC6499054
has PubMed identifier	31106060
schema:publication	PeerJ
resource representing a document's body	covid:cc8e81f5fd3efda044a42e965278d17c58bb4ea6#body_text
is schema:about of	named entity 'ANALYSIS' named entity 'CREATIVE COMMONS' named entity 'DISTRIBUTED' named entity 'SPIKE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'strains' named entity 'diarrhea' named entity 'vaccines' named entity 'contents' named entity 'endemic' named entity 'chain reaction' named entity 'genome' named entity 'caused' named entity 'Thai' named entity 'circulating' named entity 'REGIONAL' covid:arg/cc8e81f5fd3efda044a42e965278d17c58bb4ea6 named entity '2011' named entity 'SUGGEST' named entity 'IMPORTANT' named entity 'THAI' named entity 'RECENT' named entity 'TARGETING' named entity 'GENES' named entity 'CONTINUED' named entity 'OPEN READING FRAME' named entity 'PAST' named entity 'NUCLEOCAPSID' named entity 'CHARACTERIZED' named entity 'MAY BE' named entity 'FARMS' named entity 'HAVE' named entity 'POSITIVE' named entity 'REGION' named entity 'NUCLEOTIDE SEQUENCING' named entity 'EVIDENCE' named entity 'PERIODIC' named entity 'CHANGED' named entity 'AMINO ACID' named entity 'VACCINATION' named entity 'REPORTED' named entity 'SWINE' named entity 'PIG' named entity 'SPIKE' named entity 'SCREENING' named entity 'SWINE' named entity 'CHINA' named entity 'FINDINGS' named entity 'GENE' named entity 'DIVERSITY' named entity 'GENES' named entity 'THAI' named entity 'NUCLEOCAPSID' named entity 'CIRCULATING' named entity 'ORF3' named entity 'POLYMERASE CHAIN REACTION' named entity 'DECADE' named entity 'CIRCULATING' named entity 'SMALL INTESTINAL' named entity 'OUTBREAKS' named entity 'POSSESSED' named entity 'ASSIST' named entity 'MOLECULAR' named entity 'SAMPLES' named entity 'SIGNIFICANT' named entity 'FUTURE' named entity 'VACCINES' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'AGO' named entity 'RESPONSIBLE' named entity 'EVALUATION' named entity 'COMMERCIAL'

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