About: Porcine deltacoronavirus induces TLR3, IL-12, IFN-α, IFN-β and PKR mRNA expression in infected Peyer’s patches in vivo

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About: Porcine deltacoronavirus induces TLR3, IL-12, IFN-α, IFN-β and PKR mRNA expression in infected Peyer’s patches in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Porcine deltacoronavirus induces TLR3, IL-12, IFN-α, IFN-β and PKR mRNA expression in infected Peyer’s patches in vivo
Creator	Cao, Yongchang Xue, Chunyi Chen, Li Du, Yunping Huang, Songjian Xu, Zhichao Zhong, Huiling Zhou, Qingfeng
source	Elsevier; Medline; PMC
abstract	Porcine deltacoronavirus (PDCoV) is a newly identified swine enteropathogenic coronavirus that causes watery diarrhea in piglets and results in significant economic losses to the pig industry. Currently there are no effective treatments or vaccines for PDCoV. In particular, the pathogenesis of PDCoV infection is still largely unknown. In this study, we reported that inoculating conventional weaned piglets with 1 × 10(9) TCID(50) of the PDCoV CHN-GD-2016 strain by oral feeding could cause severe diarrhea. Virus RNA was detected in rectal swabs from 1 to 7 days post inoculation. In addition, microscopic lesions in small intestine were observed, and viral antigen also detected in the small intestines with PDCoV immunohistochemical staining. Importantly, PDCoV significantly induced mRNA expression of TLR3, IL-12, IFN-α, IFN-β, and PKR, the genes involved in modulation of the host immune responses, in infected Peyer's patches at 3 d.p.i., indicating that Peyer's patches play an important role in PDCoV immune responses in vivo. Collectively, our findings suggest that the observed gene expression profile might help explain immunological and pathological changes associated with PDCoV infection.
has issue date	2018-12-11(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2018.12.012
bibo:pmid	30593372
has license	no-cc
sha1sum (hex)	cca222b4308f19b432c1d9ebbdafa7bb584595c7
schema:url	https://doi.org/10.1016/j.vetmic.2018.12.012
resource representing a document's title	Porcine deltacoronavirus induces TLR3, IL-12, IFN-α, IFN-β and PKR mRNA expression in infected Peyer’s patches in vivo
has PubMed Central identifier	PMC7117130
has PubMed identifier	30593372
schema:publication	Vet Microbiol
resource representing a document's body	covid:cca222b4308f19b432c1d9ebbdafa7bb584595c7#body_text
is schema:about of	named entity 'expression' named entity 'INFECTED' named entity 'IFN' named entity 'TLR3' named entity 'MRNA EXPRESSION' named entity 'IN VIVO' named entity 'PORCINE DELTACORONAVIRUS' named entity 'IL-12' named entity '27S' named entity 'PKR' named entity 'IFN-α' named entity 'TLR3' named entity 'MDA5' named entity 'South Korea' named entity 'watery diarrhea' named entity 'vomiting' named entity 'necropsy' named entity 'effector genes' named entity 'antiviral' named entity 'mRNA expression' named entity 'Peyer's patches' named entity 'coronavirus' named entity 'nucleic acids' named entity 'Peyer's patches' named entity 'GenBank' named entity 'PEDV' named entity 'IFN' named entity 'cDNA' named entity 'PCR' named entity 'RNA' named entity 'antisense' named entity 'RIG-I' named entity 'cDNA' named entity 'Peyer's patches' named entity 'TaKaRa' named entity 'watery diarrhea' named entity 'China' named entity 'Peyer's patches' named entity 'OAS' named entity 'veterinary pathologist' named entity 'infection' named entity 'increase or decrease' named entity 'upregulation' named entity 'virus shedding' named entity 'formalin' named entity 'mRNA' named entity 'Hong Kong' named entity 'GAPDH' named entity 'Dalian' named entity 'diarrhea' named entity 'RNA' named entity 'retinoic acid' named entity 'PKR' named entity 'IL-12' named entity 'cellular immunity' named entity 'histology' named entity 'antisense' named entity 'weaned' named entity 'Biosystem' named entity 'Shanghai' named entity 'Peyer's patches' named entity 'severe diarrhea' named entity 'mRNA expression' named entity 'severe diarrhea' named entity 'protein' named entity 'virus infection' named entity 'TGEV' named entity 'weaned' named entity 'diarrhea' named entity 'infection' named entity 'IFN-α' named entity 'Peyer's patches' named entity 'immunohistochemical' named entity 'real-time PCR'

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