About: Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis?

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About: Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis? Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis?
Creator	Kobayashi, · Watanabe, · Adachi, Yukihiko Adachi, · Esteban, Kobayashi Fujita, Naoki Fujita, · Gabazza, Cesar Gabazza, · Horiike, Shinichiro Horiike, · Iwasa, · Kaito, M Kaito, Masahiko Konishi, M Konishi, Masayoshi Motoh, · Tanaka, H Tanaka, Hideaki Watanabe, Shozo Yoshinao, Iwasa
source	Medline; PMC
abstract	GB virus C (GBV-C) and hepatitis G virus (HGV) have been proposed as new viruses etiologically implicated in non-B, non-C hepatitis, but the morphology of these particular virus particles is still unknown, and most cases of non-A to E hepatitis do not relate to their infections. We tried to visualize virus-like particles (VLPs) in plasma samples from hepatitis B surface antigen- and antibody to hepatitis C virus (HCV)-negative blood donors with elevated alanine aminotransferase (ALT), and examined the association of the virus-like particles and the genomes of parenterally transmissible GBV-C/HGV. Twenty-three plasma samples, 13 with elevated ALT levels and 10 with normal ALT values, from blood donors without infections of hepatitis B virus (HBV) and HCV, were subjected to a 20%–60% sucrose density gradient centrifugation, and virus-like particles were observed by electron microscopy. GBV-C/HGV RNAs in the plasmas were tested. Virus-like particles were found in the fractions with densities of 1.15–1.16 g/ml from 12 of 13 (92.3%) plasmas with elevated ALT levels and 1 of 10 (10%) normal controls. The ultrastructural morphology of visualized VLPs was pleomorphic in size and appearance; the majority of the VLPs were 50- to 80-nm spherical particles with a 35- to 45-nm inner core and 9- to 12-nm-long surface spikelike projections. Rodlike VLPs 50–70 nm in diameter with a length of 110–160 nm were also observed in the same samples. The incidence of detection of the circulating VLPs was significantly (P < 0.001) related to elevated ALT levels, but GBV-C/HGV RNAs were detected in none of the plasmas containing the virus-like particles. Spherical VLPs are detected in HBV- and HCV-negative plasmas significantly correlated with the elevation of ALT, suggesting that they are implicated in non-B, non-C hepatitis.
has issue date	2007-03-29(xsd:dateTime)
bibo:doi	10.1007/s00795-006-0342-7
bibo:pmid	17384986
has license	no-cc
sha1sum (hex)	ccbdf76bb39d9bb187b9456d987d9014fde890ff
schema:url	https://doi.org/10.1007/s00795-006-0342-7
resource representing a document's title	Unidentified virus-like particles are detected in plasmas with elevated ALT levels: are they significant of etiological agent(s) of non-B, non-C hepatitis?
has PubMed Central identifier	PMC7087830
has PubMed identifier	17384986
schema:publication	Med Mol Morphol
resource representing a document's body	covid:ccbdf76bb39d9bb187b9456d987d9014fde890ff#body_text
is schema:about of	named entity 'plasmas' named entity 'circulating' named entity 'negative' named entity 'incidence' named entity 'observed' named entity 'plasma' named entity 'genomes' named entity 'transmissible' named entity 'DO NOT' named entity 'C HEPATITIS' named entity 'FOUND' named entity 'relate' named entity 'particles' named entity 'plasmas' named entity 'GBV-C' named entity 'levels' named entity 'normal' named entity 'ALT' named entity 'hepatitis' named entity 'plasma' named entity 'electron microscopy' named entity 'antigen' named entity 'sucrose' named entity 'VLPs' named entity 'blood donors' named entity 'HCV' named entity 'HCV' named entity 'pleomorphic' named entity 'antibody' named entity 'VLPs' named entity 'hepatitis C virus' named entity 'virus' named entity 'correlated' named entity 'fractions' named entity 'centrifuged' named entity 'serum' named entity 'Emeryville' named entity 'Japan' named entity 'EDTA' named entity 'morphologically' named entity 'virus' named entity 'HGV' named entity 'GBV-C' named entity 'plasma' named entity 'morphology' named entity 'antibody' named entity 'density gradient' named entity 'Determiner' named entity 'cloned' named entity 'VLPs' named entity 'virus' named entity 'serum' named entity 'centrifuged' named entity 'hepatitis B surface' named entity 'sucrose' named entity 'uranyl acetate' named entity 'HTLV-I' named entity 'VLPs' named entity 'plasma' named entity 'Tris-HCl' named entity 'VLPs'

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