About: Increased Urinary Angiotensin-Converting Enzyme 2 in Renal Transplant Patients with Diabetes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Increased Urinary Angiotensin-Converting Enzyme 2 in Renal Transplant Patients with Diabetes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Increased Urinary Angiotensin-Converting Enzyme 2 in Renal Transplant Patients with Diabetes
Creator	Hiremath, S Knoll, G Srivaratharajah, K Xiao, F Zimpelmann, J
source	PMC
abstract	Angiotensin-converting enzyme 2 (ACE2) is expressed in the kidney and may be a renoprotective enzyme, since it converts angiotensin (Ang) II to Ang-(1-7). ACE2 has been detected in urine from patients with chronic kidney disease. We measured urinary ACE2 activity and protein levels in renal transplant patients (age 54 yrs, 65% male, 38% diabetes, n = 100) and healthy controls (age 45 yrs, 26% male, n = 50), and determined factors associated with elevated urinary ACE2 in the patients. Urine from transplant subjects was also assayed for ACE mRNA and protein. No subjects were taking inhibitors of the renin-angiotensin system. Urinary ACE2 levels were significantly higher in transplant patients compared to controls (p = 0.003 for ACE2 activity, and p≤0.001 for ACE2 protein by ELISA or western analysis). Transplant patients with diabetes mellitus had significantly increased urinary ACE2 activity and protein levels compared to non-diabetics (p<0.001), while ACE2 mRNA levels did not differ. Urinary ACE activity and protein were significantly increased in diabetic transplant subjects, while ACE mRNA levels did not differ from non-diabetic subjects. After adjusting for confounding variables, diabetes was significantly associated with urinary ACE2 activity (p = 0.003) and protein levels (p<0.001), while female gender was associated with urinary mRNA levels for both ACE2 and ACE. These data indicate that urinary ACE2 is increased in renal transplant recipients with diabetes, possibly due to increased shedding from tubular cells. Urinary ACE2 could be a marker of renal renin-angiotensin system activation in these patients.
has issue date	2012-05-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0037649
bibo:pmid	22629438
has license	cc-by
sha1sum (hex)	cccb1a743e85a745309415410b3101c2ab1b59bb
schema:url	https://doi.org/10.1371/journal.pone.0037649
resource representing a document's title	Increased Urinary Angiotensin-Converting Enzyme 2 in Renal Transplant Patients with Diabetes
has PubMed Central identifier	PMC3358292
has PubMed identifier	22629438
schema:publication	PLoS One
resource representing a document's body	covid:cccb1a743e85a745309415410b3101c2ab1b59bb#body_text
is schema:about of	named entity 'INCREASED' named entity 'patients' named entity 'gender' named entity 'compared' named entity 'protein' named entity 'subjects' named entity 'mRNA' named entity 'RENAL' named entity 'ANGIOTENSIN' named entity 'DATA' named entity 'DIABETES' named entity '100%' named entity 'KIDNEY' named entity 'SUBJECTS' named entity 'ACTIVITY' named entity 'MRNA' named entity 'NON-' covid:arg/cccb1a743e85a745309415410b3101c2ab1b59bb named entity 'ENZYME' named entity 'PROTEIN LEVELS' named entity 'DIABETES MELLITUS' named entity 'PROTEIN' named entity '28P' named entity 'DIABETICS' named entity 'RENAL TRANSPLANT RECIPIENTS' named entity 'PATIENTS' named entity 'URINARY' named entity 'PROTEIN ' named entity 'URINARY' named entity 'HEALTHY' named entity 'IN URINE' named entity 'MEASURED' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'RENAL TRANSPLANT' named entity 'POSSIBLY' named entity 'DIABETES' named entity '0.003' named entity 'ANALYSIS' named entity 'DETERMINED' named entity 'YRS' named entity 'THESE' named entity 'TUBULAR CELLS' named entity 'MAY BE A' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'ACE' named entity 'FEMALE GENDER' named entity 'VARIABLES' named entity 'ANG' named entity 'RENAL TRANSPLANT' named entity '50%' named entity 'DID' named entity 'MALE' named entity 'LEVELS' named entity 'ACTIVATION' named entity 'TAKING' named entity 'ACE ACTIVITY' named entity 'ASSOCIATED WITH' named entity 'URINE' named entity 'DIABETIC' named entity 'COMPARED' named entity 'ADJUSTING' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'TRANSPLANT' named entity 'PATIENTS' named entity 'SHEDDING' named entity 'MARKER' named entity 'DUE TO' named entity 'ACE2' named entity 'ELEVATED' named entity 'HIGHER' named entity 'WESTERN' named entity 'INHIBITORS' named entity 'CHRONIC KIDNEY DISEASE' named entity 'INCREASED' named entity 'ELISA' named entity 'DETECTED' named entity 'EXPRESSED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software