About: Dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19
Creator	Zhang, Wei Xu, Yu Xiang, Rong Liu, Liu Zhu, Ting Xiang, Z Deng, Zhifeng Liu, Zheming Liu, Zhili Liu, ，zheming Liu, ，zhili Zhang, Deng Zhang, Minli
source	Elsevier; Medline; PMC
abstract	Abstract Introduction Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19. Methods Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 435 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and retrospectively analyzed. The counts of lymphocyte subsets at each week after the onset of the illness were compared with other weeks of illness and with those from normal individuals. Results The various lymphocyte subsets (CD3 +, CD4 +, CD8 +, CD19 +and CD16/56 +) were below the normal ranges at the first week after the onset of the illness, reaching a nadir during the second week, which increased gradually in the third week and returned to normal levels in the fifth week, but was still lower than the healthy controls. The CD3+, CD4+ and CD8+ counts were significantly lower in those with severe disease compared to those with non-severe disease, and in those patients that died compared to those who recovered. Discussion our research indicates that the levels of peripheral blood lymphocyte subsets (CD3 +, CD4 +, and CD8 +) are associated with disease progression, severity, and prognosis in patients with COVID-19. Dynamic monitoring of human immune function is one of the indicators for evaluating the severity and prognosis of COVID-19 patients, and it is helpful to formulate appropriate treatment strategies.
has issue date	2020-07-04(xsd:dateTime)
bibo:doi	10.1016/j.ijid.2020.07.003
bibo:pmid	32634585
has license	els-covid
sha1sum (hex)	ccd2cd6737088e95273ae5ffef75a13dc7bfb15b
schema:url	https://doi.org/10.1016/j.ijid.2020.07.003
resource representing a document's title	Dynamic changes of peripheral blood lymphocytes subsets in adult patients with COVID-19
has PubMed Central identifier	PMC7334931
has PubMed identifier	32634585
schema:publication	Int J Infect Dis
resource representing a document's body	covid:ccd2cd6737088e95273ae5ffef75a13dc7bfb15b#body_text
is schema:about of	named entity 'adult' named entity 'Dynamic' named entity 'COVID-19' named entity 'peripheral blood lymphocytes' named entity 'peripheral blood lymphocyte' named entity 'CD3+' named entity 'lymphocytes' named entity 'lymphocytopenia' named entity 'peripheral blood' named entity 'COVID-19' named entity 'COVID' named entity 'reverse transcriptase polymerase chain reaction' named entity 'oxygen' named entity 'lymphocytopenia' named entity 'virus' named entity 'fatigue' named entity 'COVID-19' named entity 'lymphocyte' named entity 'CD8+' named entity 'covid-19' named entity 'morbidity' named entity 'prognosis' named entity 'adaptive immunity' named entity 'peripheral blood lymphocyte' named entity 'peripheral blood lymphocyte' named entity 'H1N1' named entity 'lymphocytes' named entity 'lymphocytopenia' named entity 'lymphocytes' named entity 'China' named entity 'cell counts' named entity 'China' named entity 'CD16' named entity 'lung tissue' named entity 'SARS-CoV-2' named entity 'lymphocytes' named entity 'immune function' named entity 'COVID' named entity 'virus' named entity 'immune function' named entity 'CD3+' named entity 'bacterial infections' named entity 'lymphocytes' named entity 'immune cells' named entity 'measles' named entity 'dry cough' named entity 'coronavirus' named entity 'peripheral blood lymphocytes' named entity 'acute respiratory distress syndrome' named entity 'retrospective study' named entity 'fever' named entity 'clinical studies' named entity 'innate immunity' named entity 'SARS' named entity 'Lymphocytosis' named entity 'CD4 +' named entity 'human immune function' named entity 'lymphocytes' named entity 'viral infections' named entity 'systemic lupus erythematosus' named entity 'viral infections' named entity 'NK cells' named entity 'virus' named entity 'acute phase' named entity 'lymphocytes' named entity 'peripheral blood lymphocyte' named entity 'peripheral blood lymphocyte' named entity 'statistically significant' named entity 'COVID-19'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software