About: Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions

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About: Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions
Creator	Wang, Yue Huang, Li Li, Chen Ishag, Hassan Mao, Xiang Sun, Ming-Xia Ge, Ling-Ling Li, Peng-Peng Dai, Juan-Juan Hu, Xiao-Chun Shen, Zhi-Qiang
Source	Elsevier; Medline; PMC
abstract	Japanese encephalitis virus is one of the most common causes for epidemic viral encephalitis in humans and animals. Herein we demonstrated that cellular helicase DDX3 is involved in JEV replication. DDX3 knockdown inhibits JEV replication. The helicase activity of DDX3 is crucial for JEV replication. GST-pulldown and co-immunoprecipitation experiments demonstrated that DDX3 could interact with JEV non-structural proteins 3 and 5. Co-immunoprecipitation and confocal microscopy analysis confirmed that DDX3 interacts and colocalizes with these viral proteins and viral RNA during the infection. We determined that DDX3 binds to JEV 5′ and 3′ un-translated regions. We used a JEV-replicon system to demonstrate that DDX3 positively regulates viral RNA translation, which might affect viral RNA replication at the late stage of virus infection. Collectively, we identified that DDX3 is necessary for JEV infection, suggesting that DDX3 might be a novel target to design new antiviral agents against JEV or other flavivirus infections.
has issue date	2014-01-20(xsd:dateTime)
bibo:doi	10.1016/j.virol.2013.11.008
bibo:pmid	24418539
has license	no-cc
sha1sum (hex)	cd085b6e24fff8b446e9bd42ac3d723324407ac5
schema:url	https://doi.org/10.1016/j.virol.2013.11.008
resource representing a document's title	Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions
has PubMed Central identifier	PMC7111930
has PubMed identifier	24418539
schema:publication	Virology
resource representing a document's body	covid:cd085b6e24fff8b446e9bd42ac3d723324407ac5#body_text
is schema:about of	named entity 'JEV' named entity 'RNA' named entity 'Cellular' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'ANTIVIRAL AGENTS' named entity 'INTERACT' named entity 'TRANSLATED' named entity 'HELICASE' named entity 'DDX3' named entity 'NECESSARY' named entity 'EPIDEMIC' named entity 'TRANSLATION' named entity 'DETERMINED' named entity 'BINDS' named entity 'TARGET' named entity 'NEW' named entity 'HUMANS' named entity 'PULLDOWN' named entity 'MIGHT BE' named entity 'TRANSLATED' named entity 'REGIONS' named entity 'ANIMALS' named entity 'NON-STRUCTURAL PROTEINS' named entity 'CELLULAR' named entity 'HELICASE ACTIVITY' named entity 'VIRAL PROTEINS' named entity 'REPLICATION' named entity 'USED' named entity 'VIRUS INFECTION' named entity 'DEMONSTRATED' named entity 'CELLULAR' named entity 'CONFIRMED' named entity '80%' named entity 'EXPERIMENTS' named entity 'AFFECT' named entity 'INVOLVED' named entity 'ONE OF' named entity 'COMMON' named entity 'INTERACTING' named entity 'DESIGN' named entity 'VIRUS REPLICATION' named entity 'VIRAL' named entity 'DDX3' named entity 'VIRAL ENCEPHALITIS' named entity 'RNA REPLICATION' named entity 'GST' named entity 'FLAVIVIRUS INFECTIONS' named entity 'CAUSES' named entity 'ANALYSIS' named entity 'SYSTEM' named entity 'VIRAL RNA' named entity 'INFECTION' named entity 'IDENTIFIED' named entity 'LATE STAGE' named entity 'NOVEL' named entity 'CO-IMMUNOPRECIPITATION' named entity 'THESE' named entity 'REGIONS' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'CONFOCAL MICROSCOPY' named entity 'REPLICON' covid:arg/cd085b6e24fff8b446e9bd42ac3d723324407ac5 named entity 'inhibits' named entity 'RNA' named entity 'activity' named entity 'confocal microscopy' named entity 'proteins' named entity 'epidemic' named entity 'helicase' named entity 'replicon' named entity 'JEV'

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