About: WU polyomavirus detected in children with severe respiratory failure()

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	WU polyomavirus detected in children with severe respiratory failure()
Creator	Iwase, Noriyasu Koyama-Wakai, Chitose Miyairi, Isao Motooka, Daisuke Nakamura, Shota Shoji, Kensuke Uda, Kazuhiro
source	Elsevier; Medline; PMC
abstract	BACKGROUND: WU polyomavirus (WUPyV) is a relatively new virus associated with respiratory infections. However, its role is unclear in children with severe respiratory failure. OBJECTIVES: We aimed to evaluate the characteristics of severe respiratory failure associated with WUPyV infection in children. STUDY DESIGN: We retrospectively reviewed cases of respiratory tract infection at a tertiary children's hospital in Japan and performed real-time polymerase chain reaction (PCR) for WUPyV using residual extracted nucleic acid samples taken from respiratory tract samples of pediatric patients primarily with respiratory failure. We investigated the clinical characteristics of patients positive for WUPyV and assessed samples positive for WUPyV for other respiratory pathogens using multiplex PCR. RESULTS: WUPyV was detected in 14 of 318 specimens of respiratory tract infections. The median age was 34 months and males were predominant (n = 11, 64%). An underlying disease was found in 11 (79%) patients including five preterm and three immunocompromised patients. The most common clinical diagnosis was pneumonia (n = 13, 93%). The majority of the samples were endotracheal tube aspirates (n = 11, 79%). Other viruses were co-detected in nine (64%) patients, while WUPyV was the only pathogen detected in five patients with a history of admission to the neonatal intensive care unit. These five patients presented with fever and cough, and perihilar infiltrates were detected on chest radiograph in several days. CONCLUSIONS: WUPyV was detected in children with severe respiratory failure independently or concurrently with other pathogens. WUPyV can be a pathogen for children with a history of preterm birth or an underlying disease.
has issue date	2018-08-09(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2018.08.003
bibo:pmid	30114678
has license	no-cc
sha1sum (hex)	cd829867851242579d66e85785cf1361d170c960
schema:url	https://doi.org/10.1016/j.jcv.2018.08.003
resource representing a document's title	WU polyomavirus detected in children with severe respiratory failure()
has PubMed Central identifier	PMC7106500
has PubMed identifier	30114678
schema:publication	J Clin Virol
resource representing a document's body	covid:cd829867851242579d66e85785cf1361d170c960#body_text
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