About: Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats

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About: Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats
Creator	Kneynsberg, Andrew Kanaan, Nicholas
Source	PMC
abstract	Little is known about the specific contributions of aging to the neuron dysfunction and death in Alzheimer’s disease (AD). AD is characterized by the pathological accumulation of abnormal tau (a microtubule-associated protein), and the mislocalization of tau from the axon to the somatodendritic compartment is thought to play an important role in disease pathogenesis. The axon initial segment (AIS) is thought to play a role in the selective localization of tau in the axonal compartment. Thus, disruption in the AIS barrier may allow tau to diffuse freely back into the somatodendritic compartment and potentially lead to neurotoxicity. Here, we analyzed AISs using stereological methods and protein immunoblotting, and the localization of tau was assessed with immunofluorescence optical density measurements and protein immunoblotting. None of the outcome measurements assessed, including AIS structure, AIS protein levels, the distribution of tau in neurons of the hippocampus (HP), and total tau or phospho-tau protein levels were different in young, middle-, and old-age Fischer 344 rats. The outcome measurements assessed, including AIS structure, AIS protein levels, the distribution of tau in neurons of the HP, and total tau or phospho-tau protein levels were not different in young, middle-, and old-age Fischer 344 rats, with the exception of a small reduction in AIS volume and diameter in the CA2 region of aged animals. These data suggest that aging largely has no effect on these properties of the AIS or tau distribution, and thus, may not contribute directly to tau mislocalization.
has issue date	2017-07-21(xsd:dateTime)
bibo:doi	10.1523/eneuro.0043-17.2017
bibo:pmid	28785724
has license	cc-by
sha1sum (hex)	cde903001c25e2e1da0870eb9e40573e9fd8c424
schema:url	https://doi.org/10.1523/eneuro.0043-17.2017
resource representing a document's title	Aging Does Not Affect Axon Initial Segment Structure and Somatic Localization of Tau Protein in Hippocampal Neurons of Fischer 344 Rats
has PubMed Central identifier	PMC5520750
has PubMed identifier	28785724
schema:publication	eNeuro
resource representing a document's body	covid:cde903001c25e2e1da0870eb9e40573e9fd8c424#body_text
is schema:about of	named entity 'FISCHER 344' named entity 'exception' named entity 'tau' named entity 'stereological' named entity 'tau' named entity 'Structure' named entity '27S' named entity 'PATHOLOGICAL' named entity 'ABNORMAL' named entity 'PROTEIN IMMUNOBLOTTING' named entity 'CONTRIBUTE ' named entity 'STRUCTURE' named entity 'METHODS' named entity 'IMMUNOFLUORESCENCE' named entity 'LEAD' named entity 'MIDDLE' named entity 'DIAMETER' named entity 'PROPERTIES' named entity 'TAU PROTEIN' named entity 'DIFFERENT' named entity 'LITTLE' named entity 'OLD-AGE' named entity 'DEATH' named entity 'REDUCTION' named entity 'FISCHER 344' named entity 'DATA' named entity 'PATHOGENESIS' named entity 'IMPORTANT' named entity 'ANIMALS' named entity 'PLAY' named entity '28A' named entity 'LARGELY' named entity 'KNOWN' named entity 'NEUROTOXICITY' named entity 'FREELY' named entity 'BARRIER' named entity 'COMPARTMENT' named entity 'DIFFUSE' named entity 'DISTRIBUTION' named entity 'ASSESSED' named entity 'AGING' named entity 'SPECIFIC' named entity 'SMALL' named entity 'PROTEIN LEVELS' named entity 'SELECTIVE' named entity 'THOUGHT' named entity 'AXON INITIAL SEGMENT' named entity 'EXCEPTION' named entity 'ABOUT' named entity 'SUGGEST' named entity 'VOLUME' named entity 'NEURON' named entity 'CA2 REGION' named entity 'DISEASE' named entity 'ALLOW' named entity 'YOUNG' named entity 'DISORDERS OF THE NERVOUS SYSTEM' named entity 'AXON INITIAL SEGMENT' named entity 'RATS' named entity 'ANALYZED' named entity 'HIPPOCAMPAL' named entity 'SOMATIC' named entity 'AGING' named entity 'LOCALIZATION' named entity 'PROTEIN ' named entity 'SEGMENT STRUCTURE' named entity 'PHOSPHO' named entity 'AIS' named entity 'USING' named entity 'HIPPOCAMPUS' named entity 'NEURONS' named entity 'AGED' named entity 'SOMATODENDRITIC COMPARTMENT' named entity 'ACCUMULATION' named entity 'NO EFFECT' named entity 'OUTCOME' named entity 'CHARACTERIZED' named entity 'MICROTUBULE-ASSOCIATED PROTEIN' named entity 'ALZHEIMER' named entity 'TAU PROTEIN'

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