About: Vaccines and Therapeutics Against Hantaviruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vaccines and Therapeutics Against Hantaviruses
Creator	Lu, Lu Zhang, Fanglin Zhang, Qiang Jin, Xia Hou, Wei Cheng, Gong Han, Mingwei Liu, Rongrong Liu, Ziyu Ma, Hongwei Shu, Jiayi Wu, Xingan
Source	PMC
abstract	Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5–15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Only whole virus inactivated vaccines against HTNV or SEOV are licensed for use in the Republic of Korea and China, but the protective efficacies of these vaccines are uncertain. To a large extent, the immune correlates of protection against hantavirus are not known. In this review, we summarized the epidemiology, virology, and pathogenesis of four HFRS-causing viruses, HTNV, SEOV, PUUV, and DOBV, and two HCPS-causing viruses, ANDV and SNV, and then discussed the existing knowledge on vaccines and therapeutics against these diseases. We think that this information will shed light on the rational development of new vaccines and treatments.
has issue date	2020-01-30(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02989
bibo:pmid	32082263
has license	cc-by
sha1sum (hex)	ce0425b48e9b111a10f612fc562a2cd316633c15
schema:url	https://doi.org/10.3389/fmicb.2019.02989
resource representing a document's title	Vaccines and Therapeutics Against Hantaviruses
has PubMed Central identifier	PMC7002362
has PubMed identifier	32082263
schema:publication	Front Microbiol
resource representing a document's body	covid:ce0425b48e9b111a10f612fc562a2cd316633c15#body_text
is schema:about of	named entity 'REPUBLIC OF KOREA' named entity 'VIROLOGY' named entity 'CAUSE' named entity 'LIGHT' named entity 'HEMORRHAGIC FEVER WITH RENAL SYNDROME' named entity 'INACTIVATED VACCINES' named entity 'APPROXIMATELY' named entity 'VACCINES' named entity 'NOT KNOWN' named entity '40%' named entity 'SNV' named entity 'UNCERTAIN' named entity 'HANTAVIRUSES' named entity 'IMMUNE' named entity 'ANNUALLY' named entity 'HANTAVIRUS' named entity 'LICENSED' named entity 'INFECTIONS' named entity 'WORLDWIDE' named entity 'THINK' named entity 'RECENT' named entity 'NEW' named entity 'REVIEW' named entity 'CHINA' named entity 'VIRUS' named entity 'CASE FATALITY RATE' named entity 'AMERICAS' named entity 'THESE' named entity 'CURRENTLY' named entity 'EFFECTIVE' named entity 'UP TO' named entity 'HAVE' named entity 'VACCINES' named entity 'USE' named entity 'LARGE EXTENT' named entity 'YEARS' named entity 'THERAPEUTICS' named entity 'EITHER' named entity 'PATHOGENESIS' named entity 'PROTECTION' named entity 'INFORMATION' named entity 'CARDIOPULMONARY' named entity 'DISEASES' named entity 'TREATMENTS' named entity 'TRANSMITTED' named entity 'EURASIA' named entity 'SYNDROME' named entity 'KNOWLEDGE' named entity 'RODENT' named entity 'BUT' named entity 'DEVELOPMENT' named entity 'THERAPEUTICS' named entity 'HANTAVIRUSES' named entity 'HUMAN' named entity 'VIRUSES' named entity 'TREATMENT AVAILABLE' named entity 'HFRS' named entity 'EPIDEMIOLOGY' named entity 'CAUSING' named entity '200' named entity 'hemorrhagic fever with renal syndrome' named entity 'Hantaviruses' named entity 'Eurasia' named entity 'case fatality rate' named entity 'viruses' named entity 'viruses' named entity 'rodent' named entity 'vaccines' named entity 'efficacies' named entity 'SEOV'

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