About: Ribosomal Frameshifting in Decoding Plant Viral RNAs

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About: Ribosomal Frameshifting in Decoding Plant Viral RNAs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ribosomal Frameshifting in Decoding Plant Viral RNAs
Creator	Giedroc, David Miller, W
Source	PMC
abstract	Frameshifting provides an elegant mechanism by which viral RNA both encodes overlapping genes and controls expression levels of those genes. As in animal viruses, the −1 ribosomal frameshift site in the viral mRNA consists of a canonical shifty heptanucleotide followed by a highly structured frameshift stimulatory element, and the gene translated as a result of frameshifting usually encodes the RNA-dependent RNA polymerase. In plant viruses, the −1 frameshift stimulatory element consists of either (i) a small pseudoknot stabilized by many triple-stranded regions and a triple base pair containing a protonated cytidine at the helical junction, (ii) an unusual apical loop–internal loop interaction in which a stem-loop in the 3(′) untranslated region 4 kb downstream base pairs to a bulged stem-loop at the frameshift site, or (iii) a potential simple stem-loop. Other less well-characterized changes in reading frame occur on plant viral RNAs, including a possible +1 frameshift, and net −1 reading frame changes that do not utilize canonical frameshift signals. All these studies reveal the remarkable ways in which plant viral RNAs interact with ribosomes to precisely control protein expression at the ratios needed to sustain virus replication.
has issue date	2009-07-21(xsd:dateTime)
bibo:doi	10.1007/978-0-387-89382-2_9
has license	no-cc
sha1sum (hex)	ce174cefde63d7f44ae2e3c5656c38b3dd04e0db
schema:url	https://doi.org/10.1007/978-0-387-89382-2_9
resource representing a document's title	Ribosomal Frameshifting in Decoding Plant Viral RNAs
has PubMed Central identifier	PMC7122378
schema:publication	Recoding: Expansion of Decoding Rules Enriches Gene Expression
resource representing a document's body	covid:ce174cefde63d7f44ae2e3c5656c38b3dd04e0db#body_text
is schema:about of	named entity 'INTERNAL LOOP' named entity 'NET' named entity 'INCLUDING' named entity 'MECHANISM' named entity 'FRAMESHIFT' named entity 'PLANT VIRUSES' named entity 'INTERACT' named entity 'EITHER' named entity 'STEM-LOOP' named entity 'RATIOS' named entity 'OCCUR' named entity 'USUALLY' named entity 'SUSTAIN' named entity 'TRIPLE' named entity 'VIRAL MRNA' named entity 'HIGHLY' named entity 'CYTIDINE' named entity 'BASE PAIRS' named entity 'SIMPLE' named entity '28I' named entity 'ANIMAL VIRUSES' named entity 'RIBOSOMAL FRAMESHIFT' named entity 'FOLLOWED BY' named entity 'HELICAL' named entity 'LOOP' named entity 'ELEMENT' named entity 'AS A RESULT OF' named entity 'READING FRAME' named entity 'BULGED' named entity 'DO NOT' named entity 'SMALL' named entity 'UNTRANSLATED REGION' named entity 'BASE PAIR' named entity 'PROTONATED' named entity 'GENE' named entity 'INTERACTION' named entity 'STRUCTURED' named entity 'PROTEIN EXPRESSION' named entity 'RNAS' named entity 'DECODING' named entity 'THESE' named entity 'RNAS' named entity 'UNUSUAL' named entity 'PLANT' named entity 'PROVIDES' named entity 'LEVELS' named entity 'VIRAL RNA' named entity 'CONTAINING' named entity 'POTENTIAL' named entity 'POSSIBLE' named entity 'VIRUS REPLICATION' named entity 'TRANSLATED' named entity 'VIRAL' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'CHARACTERIZED' named entity 'APICAL' named entity '921' named entity 'SITE' named entity 'RIBOSOMAL' named entity 'PSEUDOKNOT' named entity 'EXPRESSION' named entity 'REVEAL' named entity 'NEEDED' named entity 'DOWNSTREAM' named entity 'JUNCTION' named entity 'CHANGES' named entity 'RIBOSOMES' named entity '2B1' named entity 'STABILIZED' named entity 'CONTROL' named entity 'REGIONS' named entity 'STUDIES' named entity 'SIGNALS' named entity 'PLANT' named entity 'OVERLAPPING' named entity 'VIRAL' named entity 'GENES' named entity 'protein expression' named entity 'overlapping genes' named entity 'plant viruses' named entity 'viral RNAs' named entity 'frameshift'

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