About: Oligodendroglial pathology in canine distemper

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About: Oligodendroglial pathology in canine distemper Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Oligodendroglial pathology in canine distemper
Creator	Zurbriggen, A Graber, · Schmid, · Schmid, I Vandevelde, ·
Source	PMC
abstract	Canine distemper virus (CDV) causes a multifocal demyelinating disease in dogs. The mechanism of acute demyelination in distemper is still poorly understood. The initial demyelinating lesion in distemper is directly virus induced, since there is a clear correlation between the occurrence of demyelination and CDV replication in the cells of the white matter. Yet, there is little evidence for oligodendroglial infection. Changes of these cells have been reported in vitro and in vivo. The in vitro studies showed that – in contrast to other cells such as astrocytes and macrophages – oligodendrocytes hardly express CDV protein. However, we could show that these cells underwent a restricted infection with transcription of CDV RNA and that this phenomenon correlated with down-regulation of myelin gene transcription. The extension of these in vitro findings in vivo was obscured by the lack of reliable oligodendrocyte labelling techniques in canine brain tissue sections. In this study we combined immunohistochemistry with in situ hybridization to examine oligodendrocytes in demyelinating lesions and to investigate the question of oligodendrocyte infection in vivo. We could demonstrate that CDV infection leads to massive down-regulation of myelin gene expression in demyelinating lesions and that this effect correlates in part with a restricted infection of oligodendrocytes.
has issue date	1997-01-01(xsd:dateTime)
bibo:doi	10.1007/s004010050767
bibo:pmid	9452824
has license	no-cc
sha1sum (hex)	ce8e5d6da5b29ec3504e230e74fe2e0669abf1bb
schema:url	https://doi.org/10.1007/s004010050767
resource representing a document's title	Oligodendroglial pathology in canine distemper
has PubMed Central identifier	PMC7086659
has PubMed identifier	9452824
schema:publication	Acta Neuropathol
resource representing a document's body	covid:ce8e5d6da5b29ec3504e230e74fe2e0669abf1bb#body_text
is schema:about of	named entity 'vivo' named entity 'study' named entity 'myelin' named entity 'restricted' named entity 'demyelinating lesions' named entity 'infection' named entity 'EFFECT' named entity 'EXPRESS' named entity 'RESTRICTED' named entity 'OLIGODENDROCYTE' named entity 'LESION' named entity 'COMBINED' named entity 'RNA' named entity 'transcription' named entity 'multifocal' named entity 'oligodendrocyte' named entity 'virus' named entity 'replication' named entity 'RNA' named entity 'vivo' named entity 'initial' named entity 'distemper' named entity 'The mechanism' named entity 'studies' named entity 'pathology' named entity 'infection' named entity 'demyelinating disease' named entity 'RNA' named entity 'protein' named entity 'distemper' named entity 'macrophages' named entity 'hybridization' named entity 'gene expression' named entity 'virus' named entity 'Canine distemper virus' named entity 'CDV' named entity 'brain tissue' named entity 'CDV' named entity 'oligodendrocyte' named entity 'astrocytes' named entity 'diethylpyrocarbonate' named entity 'virulent' named entity 'Texas red' named entity 'astrocytes' named entity 'infection' named entity 'ISH' named entity 'closely related' named entity 'coding region' named entity 'White matter' named entity 'oligodendrocytes' named entity 'CDV' named entity 'gene transcription' named entity 'demyelinated' named entity 'myelinated' named entity 'mRNA' named entity 'RNA' named entity 'distemper' named entity 'sodium citrate' named entity 'virus' named entity 'streptavidin' named entity 'distemper' named entity 'complementary DNA' named entity 'demyelination' named entity 'oligodendroglial' named entity 'loss of myelin' named entity 'cerebellum' named entity 'Germany' named entity 'monoclonal antibody' named entity 'infection' named entity 'down-regulation' named entity 'DNase' named entity 'mRNAs' named entity 'NaCl' named entity 'oligodendrocytes' named entity 'ISH' named entity 'GFAP' named entity 'oligodendrocytes'

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