About: Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism

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About: Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism
Creator	Imai, Kunitoshi Koich Machida, · Nakano, · Ogawa, Haruko Okuyama, Yuko Takeda, Yohei Yaoita, Yasunori
Source	PMC
abstract	Influenza A virus (IAV) infection is perennially one of the leading causes of death worldwide. Effective therapy and vaccination are needed to control viral expansion. However, current anti-IAV drugs risk inducing drug-resistant virus emergence. Although intranasal administration of whole inactivated virus vaccine can induce efficient protective immunity, formalin and β-propiolactone are the currently used and harmful inactivating agents. Here, we analyzed the antiviral activity of hibiscus (Hibiscus sabdariffa L.) tea extract against human IAV and evaluated its potential as a novel anti-IAV drug and a safe inactivating agent for whole inactivated vaccine. The in vitro study revealed that the pH of hibiscus tea extract is acidic, and its rapid and potent antiviral activity relied largely on the acidic pH. Furthermore, the mouse study showed that the acidic extract was not effective for either therapeutic or vaccination purposes. However, hibiscus tea extract and protocatechuic acid, one of the major components of the extract, showed not only potent acid-dependent antiviral activity but also weak low-pH-independent activity. The low-pH-independent activity did not affect the conformation of immunodominant hemagglutinin protein. Although this low-pH-independent activity is very limited, it may be suitable for the application to medication and vaccination because this activity is not affected by the neutral blood environment and does not lose antigenicity of hemagglutinin. Further study of the low-pH-independent antiviral mechanism and attempts to enhance the antiviral activity may establish a novel anti-IAV therapy and vaccination strategy.
has issue date	2019-10-16(xsd:dateTime)
bibo:doi	10.1007/s12560-019-09408-x
bibo:pmid	31620998
has license	no-cc
sha1sum (hex)	cebf7c1939a93b1a00fe17d0da8e674b3d69891f
schema:url	https://doi.org/10.1007/s12560-019-09408-x
resource representing a document's title	Antiviral Activities of Hibiscus sabdariffa L. Tea Extract Against Human Influenza A Virus Rely Largely on Acidic pH but Partially on a Low-pH-Independent Mechanism
has PubMed Central identifier	PMC7223586
has PubMed identifier	31620998
schema:publication	Food Environ Virol
resource representing a document's body	covid:cebf7c1939a93b1a00fe17d0da8e674b3d69891f#body_text
is schema:about of	named entity 'potent' named entity 'vaccination' named entity 'drug-resistant' named entity 'vaccination' named entity 'inactivated vaccine' named entity 'conformation' named entity 'rapid' named entity 'However' named entity 'environment' named entity 'blood' named entity 'activity' named entity 'extract' named entity 'The' named entity 'INFLUENZA A VIRUS' named entity 'hibiscus tea' named entity 'Although' named entity 'potential' named entity 'antiviral' named entity 'The' named entity 'antigenicity' named entity 'Although' named entity 'conformation' named entity 'IAV' named entity 'formalin' named entity 'hibiscus tea' named entity 'antiviral activity' named entity 'vaccination' named entity 'vaccine' named entity 'antigenicity' named entity 'IAV' named entity 'Tea' named entity 'hibiscus' named entity 'hemagglutination inhibition' named entity 'PBS' named entity 'antiviral activity' named entity 'centrifugation' named entity 'lung' named entity 'vaccine' named entity 'virus species' named entity '0.01' named entity 'p.o. administration' named entity 'influenza virus' named entity 'titer' named entity 'virus' named entity 'body weight' named entity 'hemagglutination inhibition' named entity 'IAV' named entity 'phenolic compounds' named entity 'inoculation' named entity 'conformation' named entity 'p.o. administration' named entity 'hibiscus tea' named entity 'Hib' named entity 'Hib' named entity 'virus' named entity 'virus' named entity 'conformation' named entity 'Hib' named entity 'supernatant' named entity 'intranasally' named entity 'viral particle' named entity 'aqueous' named entity 'Hib' named entity 'formalin' named entity 'virus' named entity 'hibiscus tea' named entity 'Cayman Chemical' named entity 'IAV' named entity 'trypsin' named entity 'anthocyanins' named entity 'MDCK' named entity 'IgA production' named entity 'body weight' named entity 'Japan' named entity 'polyphenols'

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