About: Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies

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About: Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies
Creator	Nikolin, V Ambagala, A Auste, A Beer, M Blome, & De Smit, H Leidenberger, S Pinette, M Schröder, Ch Zani, L
Source	Medline; PMC
abstract	Porcine epidemic diarrhea (PED) has caused tremendous losses to the United States pig industry since 2013. From 2014, outbreaks were also reported from Central Europe. To characterize the Central European PEDV strains regarding their virulence in suckling piglets, and to assess the protective effect of maternally derived antibodies (MDA), four trial groups were randomly assigned, each consisting of two pregnant sows and their litter. To induce MDA in a subset of piglets, two sows received a cell culture-adapted PEDV strain, and another two sows were inoculated with field material from German PED outbreaks. Four sows stayed naïve. Subsequently, all piglets were inoculated with the corresponding PEDV strains at an age of 3 to 6 days, and virus shedding, clinical signs and occurrence of specific antibodies were assessed. Piglets without MDA showed a morbidity of 100% and low lethality, while almost all MDA-positive piglets stayed clinically healthy and showed considerably lower virus shedding. Taken together, the Central European PEDV strains showed rather low virulence under experimental conditions, and pre-inoculation of sows led to a solid protection of their offspring. The latter is the prerequisite for a sow vaccination concept that could help to prevent PED induced losses in the piglet sector.
has issue date	2017-09-07(xsd:dateTime)
bibo:doi	10.1038/s41598-017-11160-w
bibo:pmid	28883628
has license	cc-by
sha1sum (hex)	cf4a58774b63c053feab8838400b5bb5f595d401
schema:url	https://doi.org/10.1038/s41598-017-11160-w
resource representing a document's title	Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies
has PubMed Central identifier	PMC5589859
has PubMed identifier	28883628
schema:publication	Sci Rep
resource representing a document's body	covid:cf4a58774b63c053feab8838400b5bb5f595d401#body_text
is schema:about of	named entity 'antibodies' named entity 'specific' named entity 'virulence' named entity 'losses' named entity 'PED' named entity 'piglet' named entity 'derived' named entity 'induced' named entity 'strains' named entity 'derived' named entity 'PEDV' named entity 'ANTIBODIES' named entity 'PREGNANT' named entity 'RECEIVED' named entity 'POSITIVE' named entity 'LED' named entity 'PROTECTIVE EFFECT' named entity 'SOWS' named entity 'ASSIGNED' named entity 'INDUCED' named entity 'CENTRAL' named entity 'PEDV' named entity 'GERMAN' named entity 'STRAINS' named entity 'OUTBREAKS' named entity 'SOLID' named entity 'PIGS' named entity 'INVESTIGATION' named entity 'CONCEPT' named entity 'VACCINATION' named entity 'ASSESS' named entity 'MATERIAL' named entity 'PED' named entity 'HELP' named entity 'THEIR' named entity 'MDA' named entity 'RATHER' named entity 'AGE' named entity 'HEALTHY' named entity 'MORBIDITY' named entity 'INDUCE' named entity 'REPORTED' named entity 'SECTOR' named entity 'ADAPTED' named entity 'EUROPEAN' named entity 'GROUPS' named entity 'ALMOST ALL' named entity 'LOW' named entity 'SUBSET' named entity 'TO CHARACTERIZE' named entity 'INOCULATION' named entity 'CENTRAL EUROPE' named entity 'PIGLET' named entity 'EXPERIMENTAL CONDITIONS' named entity 'SOW' named entity 'OCCURRENCE' named entity 'OFFSPRING' named entity 'DERIVED' named entity 'VIRULENCE' named entity 'ANTIBODIES' named entity 'STRAINS' named entity 'TAKEN' named entity 'SPECIFIC' named entity 'FIELD' named entity 'LOWER' named entity 'PREREQUISITE' named entity 'VIRULENCE' named entity 'PROTECTION' named entity 'DAYS' named entity 'CURRENT' named entity 'GERMAN' named entity 'TO PREVENT'

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