About: Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes
Creator	Balsano, Francesco Barnaba, Vincenzo Benvenuto, Rosalba Cesare, ~ Franco, Alessandra Ii, Paroli, Marino Testa, Ugo
source	Medline; PMC
abstract	Human activated T lymphocytes expressing class II molecules are able to present only complex antigens that bind to their own surface receptors, and thus can be captured, internalized, and processed through the class II major histocompatibility complex processing pathway. We have used the antigen-presenting T cell system to identify the viral receptor used by hepatitis B virus (HBV) to enter cells, as well as the sequence of HB envelope antigen (HBenvAg) involved in this interaction. Results show that both CD4+ and CD8+ T clones can process and present HBenvAg to class II-restricted cytotoxic T lymphocytes and that the CD71 transferrin receptor (TfR) is involved in efficient HBenvAg uptake by T cells. Moreover, we provide evidence that the HBenvAg sequence interacting with the T cell surface is contained within the pre-S2 region. Since TfR is also expressed on hepatocytes, it might represent a portal of cellular entry for HBV infection. This system of antigen presentation by T cells may serve as a model to study both lymphocyte receptors used by lymphocytotropic viruses and viral proteins critical to bind them.
has issue date	1992-05-01(xsd:dateTime)
bibo:pmid	1569393
has license	cc-by-nc-sa
sha1sum (hex)	cf6a16717c4b118d2e8bca72fe7dd28c2f2c2cdb
resource representing a document's title	Transferrin receptor mediates uptake and presentation of hepatitis B envelope antigen by T lymphocytes
has PubMed Central identifier	PMC2119224
has PubMed identifier	1569393
schema:publication	J Exp Med
resource representing a document's body	covid:cf6a16717c4b118d2e8bca72fe7dd28c2f2c2cdb#body_text
is schema:about of	named entity 'MEDIATES' named entity 'T LYMPHOCYTES' named entity 'PROVIDE' named entity 'MAJOR HISTOCOMPATIBILITY COMPLEX' named entity 'STUDY' named entity 'PORTAL' named entity 'EVIDENCE' named entity 'DASS' named entity 'MOLECULES' named entity 'CD71' named entity 'CYTOTOXIC' named entity 'REPRESENT' named entity 'BIND' named entity 'SYSTEM' named entity 'CELLS' named entity 'TRANSFERRIN RECEPTOR' named entity 'T CELLS' named entity 'CD8' named entity 'INVOLVED' named entity 'CD4' named entity 'VIRAL PROTEINS' named entity 'Since' named entity 'cytotoxic T lymphocytes' named entity 'enter' named entity 'provide' named entity 'viruses' named entity 'infection' named entity 'bind' named entity 'captured' named entity 'Antigen' named entity 'TRANSFERRIN RECEPTOR' covid:arg/cf6a16717c4b118d2e8bca72fe7dd28c2f2c2cdb named entity 'HEPATITIS B VIRUS' named entity 'SEQUENCE' named entity 'REGION' named entity 'INTERACTING' named entity 'HAVE' named entity 'T CELL' named entity 'PROCESS' named entity 'CLONES' named entity 'EFFICIENT' named entity 'TFR' named entity 'UPTAKE' named entity 'VIRUSES' named entity 'ANTIGEN' named entity 'UPTAKE' named entity 'HEPATITIS B' named entity 'ENVELOPE' named entity 'RESULTS' named entity 'PRE' named entity 'ANTIGEN PRESENTATION' named entity 'VIRAL RECEPTOR' named entity 'HEPATOCYTES' named entity 'HBV INFECTION' named entity 'RECEPTORS' named entity 'ENTER' named entity 'CELL SYSTEM' named entity 'HUMAN' named entity 'ENVELOPE' named entity 'ENTRY' named entity 'CRITICAL' named entity 'ACTIVATED' named entity 'PRESENTATION' named entity 'ANTIGEN' named entity 'USED' named entity 'CELLULAR' named entity 'T LYMPHOCYTES' named entity 'THEIR' named entity 'LYMPHOCYTE' named entity 'COMPLEX' named entity 'EXPRESSED' named entity 'CONTAINED' named entity 'RESTRICTED' named entity 'PROCESSED' named entity 'MODEL' named entity 'SURFACE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software