About: Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections

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About: Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections
Creator	Meijer, Adam Bruin, Jacob Sanders, Elisabeth Veenhoven, Reinier Luytjes, Willem De Lange, Marit Rots, Nynke Van Beek, Josine Van Boxtel, Renée
Source	Medline; PMC
abstract	BACKGROUND: Data on the relative contribution of influenza virus and other respiratory pathogens to respiratory infections in community-dwelling older adults (≥60 years) are needed. METHODS: A prospective observational cohort study was performed in the Netherlands during 2 winters. Nasopharyngeal and oropharyngeal swabs were collected during influenza-like illness (ILI) episodes and from controls. Viruses and bacteria were identified by multiplex ligation–dependent probe amplification assay and conventional bacterial culture. RESULTS: The ILI incidence in the consecutive seasons was 7.2% and 11.6%, and influenza virus caused 18.9% and 34.2% of ILI episodes. Potential pathogen were detected in 80% of the ILI events with influenza virus, coronaviruses, rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza viruses, and Haemophilus influenzae being the most common. Influenza vaccination reduced influenza virus infection by 73% (95% confidence interval [CI], 26%–90%) and 51% (95% CI, 7%–74%) in ILI patients. However, ILI incidence was similar between vaccinated (7.6% and 10.8%) and nonvaccinated (4.2% and 11.4%) participants in 2011–2012 and 2012–2013, respectively (P > .05). CONCLUSIONS: Influenza virus is a frequent pathogen in older adults with ILI. Vaccination reduces the number of influenza virus infections but not the overall number of ILI episodes: other pathogens fill the gap. We suggest the existence of a pool of individuals with high susceptibility to respiratory infections. CLINICAL TRIALS REGISTRATION: NTR3386.
has issue date	2017-08-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jix268
bibo:pmid	28931240
has license	no-cc
sha1sum (hex)	cfb1c4bf3724faafcf43342c0581ecba8baffde3
schema:url	https://doi.org/10.1093/infdis/jix268
resource representing a document's title	Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections
has PubMed Central identifier	PMC7107403
has PubMed identifier	28931240
schema:publication	J Infect Dis
resource representing a document's body	covid:cfb1c4bf3724faafcf43342c0581ecba8baffde3#body_text
is schema:about of	named entity 'PAGES' named entity 'Virus' named entity 'REDUCED' named entity 'INFLUENZA VACCINATION' named entity 'INFLUENZA-LIKE ILLNESS' named entity 'COHORT' named entity 'EDITORIAL' named entity 'COMMENTARY' named entity 'LABORATORY' named entity 'INCIDENCE' named entity 'REDUCING' named entity 'INFECTIONS' named entity 'CONFIRMED' named entity 'INFLUENZA VIRUS' named entity 'MCNEIL' covid:arg/cfb1c4bf3724faafcf43342c0581ecba8baffde3 named entity 'Incidence' named entity 'Adults' named entity 'Influenza Virus' named entity 'RSV' named entity 'pathogen' named entity 'Netherlands' named entity 'confidence interval' named entity 'ILI' named entity 'pathogens' named entity 'standard procedures' named entity 'viruses' named entity 'virus' named entity 'ILI' named entity 'average age' named entity 'viruses' named entity 'influenza' named entity 'ILI' named entity 'elderly persons' named entity 'influenza vaccination' named entity 'ILI' named entity 'logistic regression' named entity 'flu' named entity 'vaccination' named entity 'vaccination' named entity 'influenza virus' named entity 'time of flight' named entity 'H3N2' named entity 'ILI' named entity 'human metapneumovirus' named entity 'influenza virus' named entity 'relative risk' named entity 'pathogens' named entity 'potential difference' named entity 'asymptomatic' named entity 'Copan' named entity 'sample size' named entity 'ILI' named entity 'symptom' named entity 'Vaccination' named entity 'viruses' named entity 'rhinovirus' named entity 'multivariable analysis' named entity 'bacteria' named entity 'influenza' named entity 'cough' named entity 'European Centre for Disease Prevention and Control' named entity 'ILI' named entity 'comorbidity' named entity 'Vaccine effectiveness' named entity 'Netherlands' named entity 'influenza virus' named entity 'asymptomatic' named entity 'observational study' named entity 'MALDI-TOF' named entity 'vaccine effectiveness' named entity 'ILI' named entity 'antigenic'

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