About: Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

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About: Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
Creator	Andersson, Magnus Francetic, Olivera Hultgren, Scott Luna-Rico, Areli Svenmarker, Pontus Wang, Fengbin Zheng, Weili Egelman, Edward Conover, Matt Dodson, Karen Hazen, Jennie Spaulding, Caitlin Louis Schreiber Iv, Henry
Source	PMC
abstract	Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 Å resolution structure of the type 1 pilus rod using cryo-electron microscopy. Residues forming the interactive surfaces that determine the mechanical properties of the rod were maintained by selection based on a global alignment of fimA sequences. We identified mutations that did not alter pilus production in vitro but reduced the force required to unwind the rod. UPEC expressing these mutant pili were significantly attenuated in bladder infection and intestinal colonization in mice. This study elucidates an unappreciated functional role for the molecular spring-like property of type 1 pilus rods in host-pathogen interactions and carries important implications for other pilus-mediated diseases.
has issue date	2018-01-18(xsd:dateTime)
bibo:doi	10.7554/elife.31662
bibo:pmid	29345620
has license	cc-by
sha1sum (hex)	d00648209ca5de4e196a97b0655de7bd181f518e
schema:url	https://doi.org/10.7554/elife.31662
resource representing a document's title	Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
has PubMed Central identifier	PMC5798934
has PubMed identifier	29345620
resource representing a document's body	covid:d00648209ca5de4e196a97b0655de7bd181f518e#body_text
is schema:about of	named entity 'MEDIATED' named entity 'UTI' named entity 'SURFACES' named entity 'BASED' named entity 'CRYO-ELECTRON MICROSCOPY' named entity 'MICE' named entity 'CHAPERONE USHER PATHWAY' named entity 'MECHANICAL PROPERTIES' named entity 'INTESTINAL' named entity 'PILI' named entity 'CAUSE' named entity 'STUDY' named entity 'GLOBAL ALIGNMENT' named entity 'ADHESIN' named entity 'DISPLAYING' named entity 'REQUIRED' named entity 'PROPERTY' named entity 'REDUCED' named entity 'MEDIATING' named entity 'ROD' named entity 'chaperone' named entity 'type 1' named entity 'gut' named entity 'reduced' named entity 'host-pathogen interactions' named entity 'Functional' named entity 'STRUCTURE' named entity 'INTERACTIVE' named entity 'SEQUENCES' named entity 'IDENTIFIED' named entity 'DISEASES' named entity 'FORMING' named entity 'MUTANT' named entity 'MAINTAINED' named entity 'PROVIDES' named entity 'STRUCTURAL' named entity 'RESOLUTION' named entity 'DID' named entity 'COLONIZATION' named entity 'URINARY TRACT INFECTIONS' named entity 'SPRING' named entity 'TYPE 1' named entity 'RODS' named entity 'ALTER' named entity 'LIKE' named entity 'HOST-PATHOGEN INTERACTIONS' named entity 'FUNCTIONAL ROLE' named entity 'THESE' named entity 'FUNCTIONAL ROLE' named entity 'SCAFFOLD' named entity 'PRODUCTION' named entity 'UROPATHOGENIC E. COLI' named entity 'THE GUT' named entity 'FIMH' named entity 'IMPORTANT' named entity 'CARRIES' named entity 'USING' named entity 'MUTATIONS' named entity 'PILUS' named entity 'TYPE 1' named entity '4.2' named entity 'FORCE' named entity 'TIP' named entity 'DETERMINE' named entity 'PILUS' named entity 'IN VITRO' named entity 'BUT' named entity 'SELECTION' named entity 'ROD' named entity 'MOLECULAR'

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