About: Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
Creator	Choi, Eunjin Ha, Kee-Soo Lee, Chul Lee, Jung Song, Jin
topic	covid:d0464b088c3c7a939a2f1862f7e910ffd9340eeb#this
Source	Medline; PMC
abstract	PURPOSE: Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children. METHODS: Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013 and December 2015. Viral epidemiology and clinical profiles of single virus infections were evaluated. RESULTS: Of 3,505 patients, viruses were identified in 2,424 (69.1%), with the assay revealing a single virus in 1,747 cases (49.8%). While major pathogens in single virus-positive cases differed according to age, human rhinovirus (hRV) was common in patients of all ages. Respiratory syncytial virus (RSV), influenza virus (IF), and human metapneumovirus (hMPV) were found to be seasonal pathogens, appearing from fall through winter and spring, whereas hRV and adenovirus (AdV) were detected in every season. Patients with ARIs caused by RSV and hRV were frequently afebrile and more commonly had wheezing compared with patients with other viral ARIs. Neutrophil-dominant inflammation was observed in ARIs caused by IF, AdV, and hRV, whereas lymphocyte-dominant inflammation was observed with RSV A, parainfluenza virus, and hMPV. Monocytosis was common with RSV and AdV, whereas eosinophilia was observed with hRV. CONCLUSION: In combination with viral identification, recognition of virus-specific clinical and laboratory patterns will expand our understanding of the epidemiology of viral ARIs and help us to establish more efficient therapeutic and preventive strategies.
has issue date	2018-06-25(xsd:dateTime)
bibo:doi	10.3345/kjp.2018.61.6.180
bibo:pmid	29963101
has license	cc-by-nc
sha1sum (hex)	d0464b088c3c7a939a2f1862f7e910ffd9340eeb
schema:url	https://doi.org/10.3345/kjp.2018.61.6.180
resource representing a document's title	Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
has PubMed Central identifier	PMC6021362
has PubMed identifier	29963101
schema:publication	Korean J Pediatr
resource representing a document's body	covid:d0464b088c3c7a939a2f1862f7e910ffd9340eeb#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d0464b088c3c7a939a2f1862f7e910ffd9340eeb
is schema:about of	named entity 'EPIDEMIOLOGY' named entity 'REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION' named entity 'ALL AGES' named entity 'DECEMBER' named entity 'INFECTIONS' named entity 'CHILDREN' named entity 'EOSINOPHILIA' named entity 'HOSPITALIZED' named entity 'INFLUENZA VIRUS' named entity 'OBSERVED' named entity 'PERFORMED' named entity 'CONCLUSION' named entity 'LYMPHOCYTE' named entity 'ACCORDING' named entity 'IDENTIFICATION' named entity 'PREVENTIVE STRATEGIES' named entity 'RECOGNITION' named entity 'METHODS' named entity 'DETECTED' named entity 'IDENTIFIED' named entity 'ADENOVIRUS' named entity 'REVEALING' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'RSV' named entity 'MULTIPLEX' named entity 'CAUSED BY' named entity 'SEASON' named entity 'ESTABLISH' named entity 'ARI' named entity 'DOMINANT' named entity 'WHEEZING' named entity 'THERAPEUTIC' named entity 'virus' named entity 'viruses' named entity 'virus' named entity 'While' named entity 'age' named entity 'RESPIRATORY VIRUS INFECTION' named entity 'COMMON' named entity 'POSITIVE' named entity 'COMBINATION' covid:arg/d0464b088c3c7a939a2f1862f7e910ffd9340eeb named entity 'ACUTE' named entity 'SEASONAL' named entity 'MOLECULAR' named entity '2015' named entity '2849' named entity 'SPECIFIC' named entity 'AGE' named entity 'HUMAN RHINOVIRUS' named entity 'LABORATORY' named entity 'CLINICAL' named entity 'HOSPITALIZED CHILDREN' named entity 'TO DETECT' named entity 'VIRAL IDENTIFICATION' named entity 'LABORATORY' named entity 'HRV' named entity 'ASYMPTOMATIC' named entity 'EXPAND' named entity 'YEARS' named entity 'PURPOSE' named entity 'EVALUATED' named entity 'COMPARED' named entity 'FREQUENTLY' named entity 'AFEBRILE' named entity 'AVAILABILITY OF' named entity 'SINGLE' named entity 'RESPIRATORY VIRUSES' named entity 'MONOCYTOSIS' named entity 'UNDERSTANDING' named entity 'ASSAY' named entity 'RESULTS' named entity 'VIRUS' named entity 'PATIENTS' named entity 'CLINICAL'

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