About: Biological Materials: The Next Frontier for Cell-Free Synthetic Biology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Biological Materials: The Next Frontier for Cell-Free Synthetic Biology
Creator	Li, Jian Freemont, Paul Kai, Lei Kelwick, Richard Myers, Chris Webb, Alexander
topic	covid:d07c98b7ba35ae0b7b617c1e1f037654f988141d#this
Source	Medline; PMC
abstract	Advancements in cell-free synthetic biology are enabling innovations in sustainable biomanufacturing, that may ultimately shift the global manufacturing paradigm toward localized and ecologically harmonized production processes. Cell-free synthetic biology strategies have been developed for the bioproduction of fine chemicals, biofuels and biological materials. Cell-free workflows typically utilize combinations of purified enzymes, cell extracts for biotransformation or cell-free protein synthesis reactions, to assemble and characterize biosynthetic pathways. Importantly, cell-free reactions can combine the advantages of chemical engineering with metabolic engineering, through the direct addition of co-factors, substrates and chemicals –including those that are cytotoxic. Cell-free synthetic biology is also amenable to automatable design cycles through which an array of biological materials and their underpinning biosynthetic pathways can be tested and optimized in parallel. Whilst challenges still remain, recent convergences between the materials sciences and these advancements in cell-free synthetic biology enable new frontiers for materials research.
has issue date	2020-05-12(xsd:dateTime)
bibo:doi	10.3389/fbioe.2020.00399
bibo:pmid	32478045
has license	cc-by
sha1sum (hex)	d07c98b7ba35ae0b7b617c1e1f037654f988141d
schema:url	https://doi.org/10.3389/fbioe.2020.00399
resource representing a document's title	Biological Materials: The Next Frontier for Cell-Free Synthetic Biology
has PubMed Central identifier	PMC7235315
has PubMed identifier	32478045
schema:publication	Front Bioeng Biotechnol
resource representing a document's body	covid:d07c98b7ba35ae0b7b617c1e1f037654f988141d#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d07c98b7ba35ae0b7b617c1e1f037654f988141d
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