About: A Method to Identify p62's UBA Domain Interacting Proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Method to Identify p62's UBA Domain Interacting Proteins
Creator	Geetha, Thangiah Pridgeon, Julia Wooten, Marie
source	PMC
abstract	The UBA domain is a conserved sequence motif among polyubiquitin binding proteins. For the first time, we demonstrate a systematic, high throughput approach to identification of UBA domain-interacting proteins from a proteome-wide perspective. Using the rabbit reticulocyte lysate in vitro expression cloning system, we have successfully identified eleven proteins that interact with p62’s UBA domain, and the majority of the eleven proteins are associated with neurodegenerative disorders, such as Alzheimer’s disease. Therefore, p62 may play a novel regulatory role through its UBA domain. Our approach provides an easy route to the characterization of UBA domain interacting proteins and its application will unfold the important roles that the UBA domain plays.
has issue date	2003-12-12(xsd:dateTime)
bibo:doi	10.1251/bpo66
bibo:pmid	14702098
has license	no-cc
sha1sum (hex)	d09b79026117ec9faebba46a8d13aa9b23ec751e
schema:url	https://doi.org/10.1251/bpo66
resource representing a document's title	A Method to Identify p62's UBA Domain Interacting Proteins
has PubMed Central identifier	PMC302190
has PubMed identifier	14702098
schema:publication	Biol Proced Online
resource representing a document's body	covid:d09b79026117ec9faebba46a8d13aa9b23ec751e#body_text
is schema:about of	named entity 'Therefore' named entity 'application' named entity 'perspective' named entity 'proteins' named entity 'ROLES' named entity 'MAJORITY' named entity 'PLAY' named entity 'UBA DOMAIN' named entity 'ITS' named entity 'PROTEOME' named entity 'NEURODEGENERATIVE DISORDERS' named entity 'ROUTE' named entity 'HAVE' named entity 'POLYUBIQUITIN BINDING' named entity 'INTERACTING' named entity 'ALZHEIMER' named entity 'RABBIT' named entity 'USING' named entity 'TIME' named entity 'IMPORTANT' named entity 'INTERACTING' named entity 'PROVIDES' named entity 'SEQUENCE MOTIF' named entity 'PROTEINS' named entity 'METHOD' named entity '27S' named entity 'P62' named entity 'PROTEINS' named entity 'LYSATE' named entity 'WIDE' named entity 'APPROACH' named entity 'SYSTEM' named entity 'INTERACT' named entity 'NOVEL' named entity 'PLAYS' named entity 'IN VITRO' named entity 'UBA DOMAIN' named entity 'P62' named entity 'CHARACTERIZATION' named entity 'IS A' named entity 'DISEASE' named entity '27S' named entity 'BINDING PROTEINS' named entity 'IDENTIFICATION' named entity 'REGULATORY ROLE' named entity 'HIGH THROUGHPUT' named entity 'ASSOCIATED WITH' named entity 'EASY' named entity 'IDENTIFIED' named entity 'TO IDENTIFY' named entity 'APPLICATION' named entity 'EXPRESSION CLONING' named entity 'PERSPECTIVE' named entity 'CONSERVED SEQUENCE' named entity 'RETICULOCYTE' covid:arg/d09b79026117ec9faebba46a8d13aa9b23ec751e named entity 'OUR APPROACH' named entity 'identified' named entity 'Alzheimer' named entity 'route' named entity 'eleven' named entity 'binding proteins' named entity 'polyubiquitin' named entity 'interacting proteins' named entity 'reticulocyte' named entity 'proteome' named entity 'neurodegenerative disorders' named entity 'p62' named entity 'HCl' named entity 'SDS' named entity 'Reelin' named entity 'molecular weight' named entity 'kinase' named entity 'HSP27' named entity 'β-amyloid' named entity 'cell lysates' named entity 'BSA' named entity 'Human embryonic' named entity 'tyrosine kinases'

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