About: Cerebral venous volume changes and pressure autoregulation in critically ill infants

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About: Cerebral venous volume changes and pressure autoregulation in critically ill infants Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cerebral venous volume changes and pressure autoregulation in critically ill infants
Creator	Govindan, Rathinaswamy Massaro, An Metzler, Marina Wang, Yunfei Adre Du Plessis, • Al-Shargabi, Tareq Andescavage, Nickie Cristante, Caitlin Gilbert Vezina, • Govindan, Vedavalli Murnick, Jonathan Reich, Daniel Swisher, •
Source	PMC
abstract	OBJECTIVE: To determine whether ventilator-related fluctuations in cerebral blood volume (CBV) are associated with cerebral pressure passivity. STUDY DESIGN: In a prospective study of newborns undergoing positive-pressure ventilation, we calculated coherence between continuous mean arterial pressure (MAP) and cerebral near-infrared spectroscopy hemoglobin difference (HbD). Significant HbD–MAP coherence indicated cerebral pressure passivity. CBV changes were measured as the spectral power of total hemoglobin (S(HbT)) at the ventilator frequency. A regression model tested whether S(HbT) predicts cerebral pressure passivity and/or death/brain injury, controlling for birth gestational age and other factors. RESULTS: We studied 68 subjects with prematurity (n = 19), congenital heart disease (n = 11), and hypoxic–ischemic encephalopathy (n = 38). S(HbT), sedative use, and pCO(2) were positively associated, and circulating hemoglobin negatively associated, with cerebral pressure passivity (p < 0.001), which was positively associated with brain injury (p < 0.001). CONCLUSION: In sick newborns, ventilator-related CBV fluctuations may predispose to cerebral pressure passivity, which may predispose to an adverse neonatal outcome.
has issue date	2020-03-10(xsd:dateTime)
bibo:doi	10.1038/s41372-020-0626-0
bibo:pmid	32157219
has license	no-cc
sha1sum (hex)	d0df4e638918ea4046d145f6b0a22a0c0121aa7e
schema:url	https://doi.org/10.1038/s41372-020-0626-0
resource representing a document's title	Cerebral venous volume changes and pressure autoregulation in critically ill infants
has PubMed Central identifier	PMC7224055
has PubMed identifier	32157219
schema:publication	J Perinatol
resource representing a document's body	covid:d0df4e638918ea4046d145f6b0a22a0c0121aa7e#body_text
is schema:about of	named entity 'determine' named entity 'cerebral' named entity 'arterial pressure' named entity 'tested' named entity 'infants' named entity 'critically ill' named entity 'MEAN ARTERIAL PRESSURE' named entity 'MAP' named entity 'PROSPECTIVE STUDY' named entity 'SIGNIFICANT' covid:arg/d0df4e638918ea4046d145f6b0a22a0c0121aa7e named entity 'hemoglobin' named entity 'calculated' named entity 'spectral power' named entity 'HbT' named entity 'HbT' named entity 'pressure' named entity 'HbT' named entity 'congenital heart disease' named entity 'CBV' named entity 'prematurity' named entity 'ventilator' named entity 'MAP' named entity 'prematurity' named entity 'blood volume' named entity 'ventilator' named entity 'Study design' named entity 'congenital heart disease' named entity 'near-infrared spectroscopy' named entity 'sedative' named entity 'autoregulation' named entity 'critically ill' named entity 'HIE' named entity 'brain injury' named entity 'induced hypothermia' named entity 'CBF' named entity 'congenital heart disease' named entity 'cardiac surgery' named entity 'newborn infants' named entity 'critical care' named entity 'autoregulation' named entity 'hypercarbia' named entity 'HIE' named entity 'cardiac intensive care' named entity 'pressor' named entity 'brain injury' named entity 'intraventricular hemorrhage' named entity 'NIRS' named entity 'midazolam' named entity 'logistic regression' named entity 'arterial pressure' named entity 'signal-processing' named entity 'hypoplastic left heart syndrome' named entity 'Mathworks' named entity 'intensivists' named entity 'Ultrasound' named entity 'high-risk' named entity 'statistical analysis' named entity 'autoregulation' named entity 'Neuroimaging studies' named entity 'CHD' named entity 'CHD' named entity 'critically ill' named entity 'ventilator settings' named entity 'critical illness' named entity 'hemodynamics' named entity 'HIE' named entity 'autoregulation' named entity 'neuroimaging'

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