About: The Emerging Role of Rhinoviruses in Lower Respiratory Tract Infections in Children – Clinical and Molecular Epidemiological Study From Croatia, 2017

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Emerging Role of Rhinoviruses in Lower Respiratory Tract Infections in Children – Clinical and Molecular Epidemiological Study From Croatia, 2017–2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Emerging Role of Rhinoviruses in Lower Respiratory Tract Infections in Children – Clinical and Molecular Epidemiological Study From Croatia, 2017–2019
Creator	Ren, Lili Kimura, Hirokazu Ivković-Jureković, Irena Ljubin-Sternak, Sunčanica Vraneš, Jasmina Forčić, Dubravko Kolarić, Branko Meštrović, Tomislav Mijač, Maja Slović, Anamarija Tot, Tatjana Meštrovič, Tomislav
Source	Medline; PMC
abstract	Rhinoviruses (RVs) are increasingly implicated not only in mild upper respiratory tract infections, but also in more severe lower respiratory tract infections; however, little is known about species diversity and viral epidemiology of RVs among the infected children. Therefore, we investigated the rhinovirus (RV) infection prevalence over a 2-year period, compared it with prevalence patterns of other common respiratory viruses, and explored clinical and molecular epidemiology of RV infections among 590 children hospitalized with acute respiratory infection in north-western and central parts of Croatia. For respiratory virus detection, nasopharyngeal and pharyngeal flocked swabs were taken from each patient and subsequently analyzed with multiplex RT-PCR. To determine the RV species in a subset of positive children, 5′UTR in RV-positive samples has been sequenced. Nucleotide sequences of referent RV strains were retrieved by searching the database with Basic Local Alignment Tool, and used to construct alignments and phylogenetic trees using MAFFT multiple sequence alignment tool and the maximum likelihood method, respectively. In our study population RV was the most frequently detected virus, diagnosed in 197 patients (33.4%), of which 60.4% was detected as a monoinfection. Median age of RV-infected children was 2.25 years, and more than half of children infected with RV (55.8%) presented with lower respiratory tract infections. Most RV cases were detected from September to December, and all three species co-circulated during the analyzed period (2017–2019). Sequence analysis based on 5′UTR region yielded 69 distinct strains; the most prevalent was RV-C (47.4%) followed by RV-A (44.7%) and RV-B (7.9%). Most of RV-A sequences formed a distinct phylogenetic group; only strains RI/HR409-18 (along with a reference strain MF978777) clustered with RV-C strains. Strains belonging to the group C were the most diverse (41.6% identity among strains), while group B was the most conserved (71.5% identity among strains). Despite such differences in strain groups (hitherto undescribed in Croatia), clinical presentation of infected children was rather similar. Our results are consistent with newer studies that investigated the etiology of acute respiratory infections, especially those focused on children with lower respiratory tract infections, where RVs should always be considered as potentially serious pathogens.
has issue date	2019-12-03(xsd:dateTime)
bibo:doi	10.3389/fmicb.2019.02737
bibo:pmid	31849887
has license	cc-by
sha1sum (hex)	d10f84b9e2232aef0a3d90771b3f861208456d2d
schema:url	https://doi.org/10.3389/fmicb.2019.02737
resource representing a document's title	The Emerging Role of Rhinoviruses in Lower Respiratory Tract Infections in Children – Clinical and Molecular Epidemiological Study From Croatia, 2017–2019
has PubMed Central identifier	PMC6901631
has PubMed identifier	31849887
schema:publication	Front Microbiol
resource representing a document's body	covid:d10f84b9e2232aef0a3d90771b3f861208456d2d#body_text
is schema:about of	named entity 'CROATIA' named entity 'MICROBIOLOGY' named entity 'ARTICLE' named entity 'VOLUME' named entity 'WWW' named entity 'DECEMBER' named entity 'ORG' named entity 'EPIDEMIOLOGICAL STUDY' named entity 'MOLECULAR' named entity 'ROLE' named entity 'CLINICAL' named entity 'LOWER RESPIRATORY TRACT INFECTIONS' named entity 'CHILDREN' named entity '2019' named entity 'RHINOVIRUSES' covid:arg/d10f84b9e2232aef0a3d90771b3f861208456d2d named entity 'AdV' named entity 'transport medium' named entity 'viral capsid' named entity 'virus-cell interactions' named entity 'viruses' named entity 'RV-C' named entity 'primers' named entity 'virally' named entity 'X-ray' named entity 'human metapneumovirus' named entity 'turnaround time' named entity 'virus' named entity 'upper respiratory tract infection' named entity 'Demographic' named entity 'upper respiratory tract infection' named entity 'Applied Biosystems' named entity 'wheezing' named entity 'infection' named entity 'auscultation' named entity 'VP3' named entity 'RVs' named entity 'clinical symptoms' named entity 'bronchitis' named entity 'Argentina' named entity 'healthcare-associated infection' named entity 'virus' named entity 'LRTI' named entity 'antimicrobial' named entity 'nested PCR' named entity 'tachypnea' named entity 'culture methods' named entity 'viral epidemiology' named entity 'United States' named entity 'single-stranded' named entity 'rhinovirus' named entity 'etiology' named entity 'clinical samples' named entity 'enterovirus' named entity 'wheezing' named entity 'adenovirus' named entity 'rhinovirus' named entity 'coryza' named entity 'process control' named entity 'enveloped viruses' named entity 'antibiotic treatment' named entity 'influenza' named entity 'multiplex PCR' named entity 'Sequence conservation' named entity 'PCR' named entity 'OC43' named entity 'van der Linden' named entity 'interquartile range' named entity 'RV-C' named entity 'MAFFT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software