About: Immunogenicity of a DNA vaccine candidate for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunogenicity of a DNA vaccine candidate for COVID-19
Creator	Li, Dan Liu, Jiangning Qin, Chuan Wang, Bin Wang, Nianshuang Wrapp, Daniel Yan, Jian Patel, Ami Muthumani, Kar Humeau, Laurent Ramos, Stephanie Schultheis, Katherine Bao, Linlin Khoshnejad, Makan Deng, Wei Boyer, Jean Zhao, Gan Tello-Ruiz, Edgar Zhu, Xizhou Carroll, Miles Broderick, Kate Buttigieg, Karen Kim, J Mclellan, Jason Park, Daniel Reuschel, Emma Smith, Trevor Weiner, David Kim, Kevin Walters, Jewell Zaidi, Faraz Gary, Ebony Bah, Mamadou Chokkalingam, Neethu Chu, Jacqueline Kulp, Daniel Walker, Susanne Xu, Ziyang Andrade, Viviane Bhojnagarwala, Pratik Choi, Jihae Dia, Yaya Doan, Arthur Elwood, Dustin Generotti, Alison Maricic, Igor Parzych, Elizabeth Purwar, Mansi Reeder, Sophia Tursi, Nicholas Ali, Ali Amante, Dinah Herring, Timothy Pezzoli, Patrick Shah Brown, Ami Vasquez, Miguel Wu, Jiun-Ming Wu, Yuanhan Yang, Maria
Source	Medline; PMC
abstract	The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease. We have previously engineered a synthetic DNA vaccine targeting the MERS coronavirus Spike (S) protein, the major surface antigen of coronaviruses, which is currently in clinical study. Here we build on this prior experience to generate a synthetic DNA-based vaccine candidate targeting SARS-CoV-2 S protein. The engineered construct, INO-4800, results in robust expression of the S protein in vitro. Following immunization of mice and guinea pigs with INO-4800 we measure antigen-specific T cell responses, functional antibodies which neutralize the SARS-CoV-2 infection and block Spike protein binding to the ACE2 receptor, and biodistribution of SARS-CoV-2 targeting antibodies to the lungs. This preliminary dataset identifies INO-4800 as a potential COVID-19 vaccine candidate, supporting further translational study.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1038/s41467-020-16505-0
bibo:pmid	32433465
has license	cc-by
sha1sum (hex)	d117411f46b5ba9b5bae7667c356c99fda44e577
schema:url	https://doi.org/10.1038/s41467-020-16505-0
resource representing a document's title	Immunogenicity of a DNA vaccine candidate for COVID-19
has PubMed Central identifier	PMC7239918
has PubMed identifier	32433465
schema:publication	Nat Commun
resource representing a document's body	covid:d117411f46b5ba9b5bae7667c356c99fda44e577#body_text
is schema:about of	named entity 'INO' named entity 'protein' named entity 'synthetic DNA' named entity 'generate' named entity 'disease' named entity 'PREVIOUSLY' named entity 'GUINEA PIGS' named entity 'MICE' named entity 'FUNCTIONAL' named entity 'MAJOR' named entity 'IDENTIFIED' named entity 'SPIKE PROTEIN' named entity 'POTENTIAL' named entity 'STUDY' named entity 'ENGINEERED' named entity 'VACCINE' named entity 'SPECIFIC' named entity 'PRIOR' named entity 'RECEPTOR' named entity 'BUILD' named entity 'CURRENTLY' named entity 'vaccine' named entity 'clinical study'

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