About: Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator

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About: Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator
Creator	Kim, Taeyeon Kim, Kwang-Sun Lee, Juyeon
Source	Medline; PMC
abstract	BACKGROUND: Ribonuclease III (RNase III) activity modulates hundreds of genes in Escherichia coli (E. coli). YmdB, a member of the macrodomain protein family, is one of known trans-acting regulators of RNase III activity; however, the significance of its regulatory role in specific bacterial cellular processes and related genes has not been determined. YmdB overexpression was used to model YmdB-induced RNase III inhibition in vivo, and microarray analysis identified gene targets and cellular processes related to RNase III inhibition. RESULTS: The expression of >2,000 E. coli genes was modulated by YmdB induction; 129 genes were strongly regulated, of which 80 have not been reported as RNase III targets. Of these, ten are involved in biofilm formation. Significantly, YmdB overexpression also inhibited biofilm formation via a process that is not uniquely dependent upon RNase III inhibition. Moreover, biofilm formation is interdependently regulated by RpoS, a known stress response regulator and biofilm inhibitor, and by YmdB. CONCLUSIONS: This is the first global profile of target genes modulated by YmdB-induced RNase III inhibition in E. coli, and the data reveal a novel, hitherto unrecognized regulatory role for YmdB in biofilm modulation.
has issue date	2013-11-24(xsd:dateTime)
bibo:doi	10.1186/1471-2180-13-266
bibo:pmid	24267348
has license	cc-by
sha1sum (hex)	d1465b112750748b01edc7837f005803a6e87658
schema:url	https://doi.org/10.1186/1471-2180-13-266
resource representing a document's title	Escherichia coli YmdB regulates biofilm formation independently of its role as an RNase III modulator
has PubMed Central identifier	PMC4222554
has PubMed identifier	24267348
schema:publication	BMC Microbiol
resource representing a document's body	covid:d1465b112750748b01edc7837f005803a6e87658#body_text
is schema:about of	named entity 'Results' named entity 'biofilm' named entity 'genes' named entity 'biofilm' named entity 'genes' named entity 'MODULATOR' covid:arg/d1465b112750748b01edc7837f005803a6e87658 named entity 'INDUCED' named entity 'YMDB' named entity '3E2' named entity 'HAVE' named entity 'GENE' named entity 'ITS' named entity 'RESULTS' named entity 'RNASE III' named entity 'ACTIVITY' named entity 'STRESS RESPONSE' named entity 'OVEREXPRESSION' named entity 'RIBONUCLEASE III' named entity 'INVOLVED' named entity 'ESCHERICHIA COLI' named entity 'ITS' named entity 'SIGNIFICANCE' named entity 'PROCESS' named entity 'INHIBITED' named entity 'INHIBITOR' named entity 'BIOFILM FORMATION' named entity 'YMDB' named entity 'ROLE' named entity 'MODULATED' named entity 'PROTEIN FAMILY' named entity '129' named entity 'MEMBER OF' named entity 'BACTERIAL' named entity 'ONE OF' named entity 'BACKGROUND' named entity 'RELATED' named entity 'TRANS' named entity 'BIOFILM FORMATION' named entity 'MODEL' named entity 'REGULATED' named entity 'MICROARRAY ANALYSIS' named entity 'REGULATORS' named entity 'RNASE III ACTIVITY' named entity 'DEPENDENT' named entity 'GENES' named entity 'IN VIVO' named entity 'TARGETS' named entity 'BIOFILM' named entity 'RNASE III' named entity 'RESPONSE REGULATOR' named entity 'INDUCTION' named entity 'EXPRESSION' named entity 'E. COLI' named entity 'III' named entity 'REGULATORY ROLE' named entity 'CELLULAR PROCESSES' named entity 'SPECIFIC' named entity 'THESE' named entity 'REPORTED' named entity 'DETERMINED' named entity 'KNOWN' named entity 'IDENTIFIED' named entity 'ESCHERICHIA COLI' named entity 'INHIBITION' named entity 'USED' named entity 'RPOS' named entity 'process' named entity 'targets' named entity 'regulated' named entity 'targets' named entity 'regulated' named entity 'modulates' named entity 'Background' named entity 'RNase III' named entity 'RNase III' named entity 'inhibition' named entity 'E. coli' named entity 'stress response'

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