About: Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease

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About: Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
Creator	Kremsner, Peter Meyer, Christian Andrade, Fabiana Cláudia, Kárita De Messias-Reason, Iara Lidani, Freitas Sandri, Thaisa Velavan, Thirumalaisamy
Source	Medline; PMC
abstract	Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Distinct CR1 exon 29 variants have been found associated with CR1 expression levels, increased susceptibility and pathophysiology of several diseases. In this study, CR1 plasma levels were assessed by ELISA and CR1 variants in exon 29 by sequencing in a Brazilian cohort of 232 chronic CD patients and 104 healthy controls. CR1 levels were significantly decreased in CD patients compared to controls (p < 0.0001). The CR1 rs1704660G, rs17047661G and rs6691117G variants were significantly associated with CD and in high linkage disequilibrium. The CR1AGAGTG haplotype was associated with T. cruzi infection (p = 0.035, OR 3.99, CI 1.1-14.15) whereas CR1AGGGTG was related to the risk of chagasic cardiomyopathy (p = 0.028, OR 12.15, CI 1.13-113). This is the first study that provides insights on the role of CR1 in development and clinical presentation of chronic CD.
has issue date	2018-01-11(xsd:dateTime)
bibo:doi	10.1038/s41598-017-18937-z
bibo:pmid	29323238
has license	cc-by
sha1sum (hex)	d15dfd546e238b29cacf7f28b83eb1cdb98f6ca8
schema:url	https://doi.org/10.1038/s41598-017-18937-z
resource representing a document's title	Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
has PubMed Central identifier	PMC5765048
has PubMed identifier	29323238
schema:publication	Sci Rep
resource representing a document's body	covid:d15dfd546e238b29cacf7f28b83eb1cdb98f6ca8#body_text
is schema:about of	named entity 'CHRONIC' named entity 'LEVELS' named entity 'PATIENTS' named entity 'HUMAN' named entity 'COHORT' named entity 'COMPLEMENT' named entity 'CHAGAS DISEASE' named entity 'HUMAN' named entity 'GENETIC' named entity 'DISTINCT' named entity 'EXPRESSION' named entity '0.035' named entity 'DISEASES' named entity 'PLAYS' named entity 'INFECTION' named entity 'LINKAGE DISEQUILIBRIUM' named entity 'EXON' named entity 'ENTRY' named entity 'COMPLEMENT RECEPTOR 1' named entity 'HAVE' named entity 'INSIGHTS' named entity 'ELISA' named entity 'VARIANTS' named entity 'HEALTHY' named entity 'DEVELOPMENT' named entity 'CHRONIC' named entity 'COMPLEMENT RECEPTOR TYPE 1' named entity 'PROTEIN LEVELS' named entity 'ROLE' named entity 'FOUND' named entity '232' named entity 'INCLUDING' named entity 'INCREASED SUSCEPTIBILITY' named entity 'VARIANTS' named entity 'RISK OF' named entity 'RELATED' named entity 'CONTRIBUTING' named entity 'MOLECULES' named entity 'HAPLOTYPE' named entity 'HOST CELLS' named entity 'PLASMA' named entity 'CLEARANCE' named entity 'COMPARED' named entity 'CLINICAL PRESENTATION' named entity 'ESSENTIAL ELEMENT' named entity 'ACQUIRED IMMUNITY' named entity 'DISORDERS' named entity 'SEQUENCING' named entity 'HIGH' named entity '028' named entity 'CARDIOMYOPATHY' named entity 'ASSOCIATED WITH' named entity 'IMMUNOPATHOGENESIS' named entity 'CR1' named entity 'BRAZILIAN' named entity 'DECREASED' named entity 'PATHOGENS' named entity '3.99' named entity '104' named entity '1.1' named entity 'CHAGAS DISEASE' named entity '28P' named entity 'PROVIDES' named entity 'STUDY' named entity 'ASSESSED' named entity 'PATHOPHYSIOLOGY' covid:arg/d15dfd546e238b29cacf7f28b83eb1cdb98f6ca8 named entity 'complement receptor 1' named entity 'exon' named entity 'CR1' named entity 'plasma levels' named entity '1.1' named entity 'CR1' named entity 'expression levels'

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