About: Effect of corticosteroid treatment on 1376 hospitalized COVID-19 patients. A cohort study.

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of corticosteroid treatment on 1376 hospitalized COVID-19 patients. A cohort study.
Creator	Affiliations, M Natalini, Giuseppe Albani, Filippo Capotosto, Cristina Ceracchi, Claudia Fusina, Federica Gargaruti, Riccardo Granato, Enza Santangelo, Giovanni Schiavone, Luca Taranto, Maria Tosati, Cinzia Vavassori, Elena
Source	MedRxiv
abstract	Background: Since the start of the novel coronavirus 2019 (COVID-19) pandemic, corticosteroid use has been the subject of debate. The available evidence is uncertain, and knowledge on the subject is evolving. The aim of our cohort study was to evaluate the association between corticosteroid therapy and hospital mortality, in patients hospitalized with COVID-19 after balancing for possible confounders. Results: One thousand four hundred forty four patients were admitted to our hospital with a positive RT-PCR test for SARS-CoV-2, 559 patients (39%) were exposed to corticosteroids during hospital stay, 844 (61%) were not exposed to corticosteroids.In the cohort of patients exposed to corticosteroids, 171 (30.6%) died. In the cohort of patients not exposed to corticosteroids, 183 (21.7%) died (unadjusted p <0.001). Nonetheless, exposure to corticosteroids was not associated with in-hospital mortality after balancing with overlap weight propensity score (adjusted p = 0.25). Patients in the corticosteroids cohort had reduced risk of ICU admission (adjusted p <0.001). Conclusions: Treatment with corticosteroids did not affect hospital mortality in patients with COVID-19 after balancing for confounders. A possible advantage of corticosteroid therapy was to reduce Intensive Care Unit admission, which could be useful in reducing pressure on the Intensive Care Units in times of limited resources, as during the COVID-19 pandemic.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1101/2020.07.17.20155994
has license	medrxiv
sha1sum (hex)	d16e9fe142ca7979f40cc830d44a8d7d9cdf9768
schema:url	https://doi.org/10.1101/2020.07.17.20155994
resource representing a document's title	Effect of corticosteroid treatment on 1376 hospitalized COVID-19 patients. A cohort study.
resource representing a document's body	covid:d16e9fe142ca7979f40cc830d44a8d7d9cdf9768#body_text
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