About: Fat mass affects nutritional status of ICU COVID-19 patients

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fat mass affects nutritional status of ICU COVID-19 patients
Creator	Bilotta, Federico De Lorenzo, Antonino Gualtieri, Paola Falcone, Carmela Ferrarelli, Anna Labate, Demetrio Macheda, Sebastiano Romano, Lorenzo Renzo, Laura Tarsitano, Maria Tescione, Marco
source	Medline; PMC
abstract	BACKGROUND: Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is the organ playing the crucial role. So, it is necessary to evaluate fat mass and not simpler body mass index (BMI), because BMI leaves a portion of the obese population unrecognized. The aim is to evaluate the relationship between Percentage of Fat Mass (FM%) and immune-inflammatory response, after 10 days in Intensive Care Unit (ICU). METHODS: Prospective observational study of 22 adult patients, affected by COVID-19 pneumonia and admitted to the ICU and classified in two sets: (10) lean and (12) obese, according to FM% and age (De Lorenzo classification). Patients were analyzed at admission in ICU and at 10th day. RESULTS: Obese have steatosis, impaired hepatic function, compromise immune response and higher inflammation. In addition, they have a reduced prognostic nutritional index (PNI), nutritional survival index for ICU patients. CONCLUSION: This is the first study evaluating FM% in COVID-19 patient. We underlined obese characteristic with likely poorly prognosis and an important misclassification of obesity. A not negligible number of patients with normal BMI could actually have an excess of adipose tissue and therefore have an unfavorable outcome such as an obese. Is fundamental personalized patients nutrition basing on disease phases.
has issue date	2020-08-03(xsd:dateTime)
bibo:doi	10.1186/s12967-020-02464-z
bibo:pmid	32746930
has license	cc-by
sha1sum (hex)	d21d5102b9e1e76889d79cd888fe79ca0de58c6a
schema:url	https://doi.org/10.1186/s12967-020-02464-z
resource representing a document's title	Fat mass affects nutritional status of ICU COVID-19 patients
has PubMed Central identifier	PMC7397427
has PubMed identifier	32746930
schema:publication	J Transl Med
resource representing a document's body	covid:d21d5102b9e1e76889d79cd888fe79ca0de58c6a#body_text
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