About: Natural product-derived phytochemicals as potential agents against coronaviruses: a review

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About: Natural product-derived phytochemicals as potential agents against coronaviruses: a review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Natural product-derived phytochemicals as potential agents against coronaviruses: a review
Creator	Broszczak, Daniel Johnson, Joel Mani, Janice Naiker, Mani Neilsen, Paul Steel, Jason Walsh, Kerry
Source	Elsevier; Medline; PMC
abstract	Abstract Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.197989
bibo:pmid	32360300
has license	els-covid
sha1sum (hex)	d280fe9f961472d75fa98a10f73bb373d418905e
schema:url	https://doi.org/10.1016/j.virusres.2020.197989
resource representing a document's title	Natural product-derived phytochemicals as potential agents against coronaviruses: a review
has PubMed Central identifier	PMC7190535
has PubMed identifier	32360300
schema:publication	Virus Res
resource representing a document's body	covid:d280fe9f961472d75fa98a10f73bb373d418905e#body_text
is schema:about of	named entity 'authors' named entity 'equally' named entity 'phytochemicals' named entity 'chemical library' named entity 'coronavirus' named entity 'IC50' named entity 'ACE' named entity 'glycyrrhizin' named entity 'IC50' named entity 'Chinese medicinal herbs' named entity 'double bond' named entity 'HCoV-229E' named entity 'glycyrrhizic acid' named entity 'viral pathogens' named entity 'adenocarcinoma' named entity 'Ebola' named entity 'antiviral activity' named entity 'phytochemicals' named entity 'red alga' named entity 'host response' named entity 'MERS-CoV' named entity 'Psoralea corylifolia' named entity 'CoV' named entity 'proteases' named entity 'EC50' named entity 'Griffithsin' named entity 'endemic' named entity 'phagolysosomes' named entity 'treatment of cancer' named entity 'COVID' named entity 'FCoV' named entity 'stomach' named entity 'feline coronavirus' named entity 'Chinese medicinal herbs' named entity 'EC50' named entity 'phytochemicals' named entity 'quercetin' named entity 'enzyme' named entity 'antiviral' named entity 'coronavirus disease' named entity 'lycorine' named entity 'COVID-19 pandemic' named entity 'spike protein' named entity 'antiallergic' named entity 'MERS-CoV' named entity 'coronavirus' named entity 'enzyme' named entity 'FIPV' named entity 'Silvestrol' named entity 'rhamnoside' named entity 'Griffithsia' named entity '4.2' named entity 'stictic acid' named entity 'bioavailability' named entity 'spike protein' named entity 'Griffithsin' named entity 'psoralidin' named entity 'caffeic acid' named entity 'IC50' named entity 'human coronavirus' named entity 'RNA viruses' named entity 'not-for-profit' named entity 'terpenoids' named entity 'Coronaviridae' named entity 'antiviral activity' named entity 'lopinavir' named entity 'IC50' named entity 'Myricetin' named entity 'antiviral activity' named entity 'host response' named entity 'virus' named entity 'non-polar' named entity 'EC50' named entity 'clinical trials' named entity 'World Health Organisation'

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