About: Effect of statins on SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Effect of statins on SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effect of statins on SARS-CoV-2 infection
Creator	Brogden, Graham Kluge, Stefan Pietschmann, Thomas Gerold, Gisa Kirui, Jared Lasswitz, Lisa Moeller, Rebecca Zapatero-Belinchón, Francisco Wichmann, Dominic Gunesch, Antonia
source	MedRxiv
abstract	The retrospective analysis of clinical data of patients suffering from COVID-19 has indicated that statin therapy, used to lower plasma cholesterol levels, is associated with a better clinical outcome. We therefore investigated the effect of statins on SARS-CoV-2 infection and found that selective statins reduced SARS-CoV-2 cell entry and inhibited high and low pathogenic coronavirus infection in human cells. A retrospective study on hospitalized patients with COVID-19 implies that reduced high density lipoprotein levels, which are typically counteracted by statin therapy, are associated with aggravated disease outcome. These results suggest that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that some statins may have a mild beneficial effect on COVID-19 outcome.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.13.20152272
has license	medrxiv
sha1sum (hex)	d2898efc13e003ea8792d1c500d50f76d65de932
schema:url	https://doi.org/10.1101/2020.07.13.20152272
resource representing a document's title	Effect of statins on SARS-CoV-2 infection
resource representing a document's body	covid:d2898efc13e003ea8792d1c500d50f76d65de932#body_text
is schema:about of	named entity 'statins' named entity 'recombinant' named entity 'rosuvastatin' named entity 'gene' named entity 'COVID' named entity 'incidence of death' named entity 'SARS-CoV-2' named entity 'medRxiv' named entity '293T cells' named entity 'peer review' named entity 'COVID-19' named entity 'animal models' named entity 'statin' named entity 'infection' named entity 'Charité' named entity 'epithelial cells' named entity 'medRxiv' named entity 'viral RNA' named entity 'control group' named entity 'Charité' named entity 'SARS-CoV-2' named entity 'Germany' named entity 'infection' named entity 'collagen' named entity 'hybridoma' named entity 'VSV' named entity 'VSV' named entity 'dose-response' named entity 'serum' named entity 'cell lysates' named entity 'serum' named entity 'ACE2 receptor' named entity 'Hamburg' named entity 'plasma membrane' named entity 'peer review' named entity 'infection' named entity 'Roche' named entity 'neutrophil' named entity 'Penicillin' named entity 'fluvastatin' named entity 'preprint' named entity 'VSV-G' named entity 'firefly luciferase' named entity 'Huh7' named entity 'SARS-CoV-2' named entity 'epithelial cells' named entity '2019-nCoV' named entity 'cell line' named entity 'COVID-19' named entity 'open reading frame' named entity 'ACE2' named entity 'fluvastatin' named entity 'DMEM' named entity '1.6' named entity 'ACE2 receptor' named entity 'Berlin' named entity 'immunomodulatory' named entity 'statistical significance' named entity 'reagent' named entity 'Calu-3' named entity 'infection' named entity 'SARS-CoV-2' named entity 'atorvastatin' named entity 'pravastatin' named entity 'Calu-3' named entity 'statins' named entity 'Fluvastatin' named entity 'cholesterol depletion' named entity 'biological replicates' named entity 'infection' named entity 'statins' named entity 'University Medical Center Hamburg-Eppendorf' named entity 'statins' named entity 'preprint' named entity 'statins' named entity 'SARS-CoV-2'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software