About: Prospective Observational Study on the Association Between Serum Mannose-Binding Lectin Levels and Severe Outcome in Critically Ill Patients with Pandemic Influenza Type A (H1N1) Infection

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About: Prospective Observational Study on the Association Between Serum Mannose-Binding Lectin Levels and Severe Outcome in Critically Ill Patients with Pandemic Influenza Type A (H1N1) Infection Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prospective Observational Study on the Association Between Serum Mannose-Binding Lectin Levels and Severe Outcome in Critically Ill Patients with Pandemic Influenza Type A (H1N1) Infection
Creator	Segard, Christine Zogheib, Elie Sendid, Boualem Jounieaux, Vincent Chouaki, • Cornu, Marjorie Dupont, • Julien Maizel, • Monconduit, Julien Nyga, Remy
topic	covid:d2a99f3617cea44e73c60249cf5fff5dc7c701c6#this
Source	PMC
abstract	BACKGROUND: Mannose-binding lectin (MBL) plays an important role in the innate immune response. In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. Our aim was to determine if serum MBL levels correlate with the risk of mortality in intensive care units (ICU) patients with A(H1N1)pdm09 infection. METHODS: Prospective observational study was performed in ICU patients with acute respiratory distress syndrome due to influenza A(H1N1)pdm09 virus. Demographic characteristics and severity indices were recorded at ICU admission. MBL was assayed from blood drawn at influenza diagnosis within 24–48 h following the ICU admission. Outcomes were compared according to MBL levels. Results are expressed as median and interquartile range. RESULTS: Serum MBL levels were studied in 27 patients (age: 56 [IQR 29] years) with severe A(H1N1)pdm09 infection and in 70 healthy controls. Median admission SAPSII and SOFA scores were 49 [IQR 26] and 12 [IQR 5], respectively. Mortality rate after a 30-day was 37%. MBL was significantly higher in non-survivors (3741 [IQR 2336] ng/ml) vs survivors (215 [IQR 1307] ng/ml), p = 0.006, as well as control group (1814 [IQR 2250] ng/ml), p = 0.01. In contrast, MBL levels in survivors group were significantly lower than the controls group (215 [IQR 1307] ng/ml vs. 1814 [IQR 2250] ng/ml, p = 0.005). MBL cut-off > 1870 ng/ml had a sensitivity of 80% and a specificity of 88.2% for mortality [AUC = 0.82 (95% CI 0.63–0.94)]. Kaplan–Meier analysis demonstrated a strong association between MBL levels and mortality (log-rank 7.8, p = 0.005). MBL > 1870 ng/ml was independently associated with mortality (HR = 8.7, 95% CI 1.2–29.1, p = 0.007). CONCLUSIONS: This study shows that baseline MBL > 1870 ng/ml is associated with higher mortality in ICU patients with severe A(H1N1)pdm09 infection.
has issue date	2017-12-22(xsd:dateTime)
bibo:doi	10.1007/s00408-017-0067-5
bibo:pmid	29273833
has license	no-cc
sha1sum (hex)	d2a99f3617cea44e73c60249cf5fff5dc7c701c6
schema:url	https://doi.org/10.1007/s00408-017-0067-5
resource representing a document's title	Prospective Observational Study on the Association Between Serum Mannose-Binding Lectin Levels and Severe Outcome in Critically Ill Patients with Pandemic Influenza Type A (H1N1) Infection
has PubMed Central identifier	PMC7101572
has PubMed identifier	29273833
schema:publication	Lung
resource representing a document's body	covid:d2a99f3617cea44e73c60249cf5fff5dc7c701c6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/d2a99f3617cea44e73c60249cf5fff5dc7c701c6
is schema:about of	named entity 'scores' named entity 'infection' named entity 'infection' named entity 'Mortality rate' named entity 'admission' named entity 'MBL' named entity 'group' named entity 'IQR' named entity 'intensive care units' named entity 'age' named entity 'strong' named entity 'Patients' named entity 'GROUP' named entity 'OUTCOMES' named entity 'SEVERITY' named entity 'RESULTS' named entity 'DEMOGRAPHIC CHARACTERISTICS' named entity 'SERUM' named entity 'YEARS' named entity '80%' named entity 'SEVERE' named entity 'BLOOD' named entity 'A(H1N1)' named entity 'MBL' named entity 'severe' named entity 'determine' named entity 'demonstrated' named entity 'influenza A' named entity 'Demographic' named entity 'sensitivity' named entity 'IQR' named entity 'ICU' named entity 'patients' named entity 'complement' named entity 'MBL' named entity 'Ill' named entity 'Serum' named entity 'MBL' named entity 'serum' named entity 'ICU' named entity '95% CI' named entity 'MBL' named entity 'infection' named entity 'MBL' named entity 'interquartile range' named entity 'cut-off' named entity 'ICU' named entity 'MBL' named entity 'IQR' named entity 'Serum' named entity 'Mortality rate' named entity 'IQR' named entity 'Pandemic Influenza' named entity 'Critically Ill Patients' named entity 'Mannose-Binding Lectin' named entity 'pro-inflammatory cytokines' named entity 'virus infection' named entity 'glycans' named entity 'immunodeficiency' named entity 'serum' named entity 'virus' named entity 'heterozygotes' named entity 'MBL' named entity 'Belgium' named entity 'diluent' named entity 'virus' named entity 'influenza' named entity 'physiology' named entity 'phagocytes' named entity 'MBL'

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