About: The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro

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About: The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro
Creator	Zhuang, Hui Tong, Yigang Zhou, Yi-Hua Li, Tong Wang, Liqin Fan, Huahao Chen, Yangzhen Hong, Bixia Hu, Yunjia Jin, Xiangshu Luo, Yuqian Xiang, Kuanhui
source	BioRxiv
abstract	Since the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human breastmilk, little is known about the antiviral property of human breastmilk to SARS-CoV-2 and its related pangolin coronavirus (GX_P2V). Here we present for the first time that whey protein from human breastmilk effectively inhibited both SARS-CoV-2 and GX_P2V by blocking viral attachment, entry and even post-entry viral replication. Moreover, human whey protein inhibited infectious virus production proved by the plaque assay. We found that whey protein from different species such as cow and goat also showed anti-coronavirus properties. And commercial bovine milk also showed similar activity. Interestingly, the main antimicrobial components of breastmilk, such as Lactoferrin and IgA antibody, showed limited anti-coronavirus activity, indicating that other factors of breastmilk may play the important anti-coronavirus role. Taken together, we reported that whey protein inhibits SARS-CoV-2 and its related virus of GX_P2V. These results rule out whey protein as a direct-acting inhibitor of SARS-CoV-2 and GX_P2V infection and replication and further investigation of its molecular mechanism of action in the context of COVID-19.
has issue date	2020-08-18(xsd:dateTime)
bibo:doi	10.1101/2020.08.17.254979
has license	biorxiv
sha1sum (hex)	d2b64b23e2330609e171acf846257eb5f5a10f1a
schema:url	https://doi.org/10.1101/2020.08.17.254979
resource representing a document's title	The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro
schema:publication	bioRxiv
resource representing a document's body	covid:d2b64b23e2330609e171acf846257eb5f5a10f1a#body_text
is schema:about of	named entity 'antimicrobial' named entity 'whey protein' named entity 'breastmilk' named entity 'goat' named entity 'REPORTED' named entity 'INDICATING' named entity 'LACTOFERRIN' named entity 'RULE OUT' named entity 'SARS-COV-2' named entity 'IMPORTANT' named entity 'PROTEIN ' named entity 'KNOWN' named entity 'MOLECULAR MECHANISM' named entity 'TIME' named entity 'ACTIVITY' named entity 'PLAQUE ASSAY' named entity 'human' named entity 'activity' named entity 'whey protein' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'virus' named entity 'detection' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'whey protein' named entity 'whey protein' named entity 'coronavirus' named entity 'COVID' named entity 'bovine milk' named entity 'SARS-CoV-2' named entity 'infection' named entity 'breastmilk' named entity 'whey protein' named entity 'breastmilk' named entity 'viral replication' named entity 'whey protein' named entity 'virus' named entity 'coronavirus' named entity 'pangolin' named entity 'informed consent' named entity 'breastmilk' named entity 'lysed' named entity 'SARS-CoV-2 virus' named entity 'SARS-CoV-2' named entity 'breastmilk' named entity 'SARS-CoV-2' named entity 'antiviral' named entity 'SARS-CoV-2' named entity 'infection' named entity 'world Health Organization' named entity 'SARS-CoV-2' named entity 'breastmilk' named entity 'infection' named entity 'supernatant' named entity 'SARS-CoV-2' named entity 'Vero E6 cells' named entity 'whey protein' named entity 'breastmilk' named entity 'antiviral' named entity 'SARS-CoV-2' named entity 'pseudovirus' named entity 'SARS-CoV-2' named entity 'breastmilk' named entity 'virus' named entity 'breastmilk' named entity 'mRNA' named entity 'viruses' named entity 'pseudovirus' named entity 'SARS-CoV-2' named entity 'antibodies' named entity 'COVID' named entity 'Manassas' named entity 'viruses'

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