About: Evaluation of Pool-based Testing Approaches to Enable Population-wide Screening for COVID-19

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of Pool-based Testing Approaches to Enable Population-wide Screening for COVID-19
Creator	Wolff, D Bittner, And Bittner, Martin-Immanuel Dirk Pflüger, D Dphil, M Heuer Msc, Janin Rehme Msc, Michael Timo, D
Source	ArXiv
abstract	Background: Rapid testing for an infection is paramount during a pandemic to prevent continued viral spread and excess morbidity and mortality. This study aimed to determine whether alternative testing strategies based on sample pooling can increase the speed and throughput of screening for SARS-CoV-2. Methods: A mathematical modelling approach was chosen to simulate six different testing strategies based on key input parameters (infection rate, test characteristics, population size, testing capacity etc.). The situations in five countries (US, DE, UK, IT and SG) currently experiencing COVID-19 outbreaks were simulated to reflect a broad variety of population sizes and testing capacities. The primary study outcome measurements that were finalised prior to any data collection were time and number of tests required; number of cases identified; and number of false positives. Findings: The performance of all tested methods depends on the input parameters, i.e. the specific circumstances of a screening campaign. To screen one tenth of each country's population at an infection rate of 1% - e.g. when prioritising frontline medical staff and public workers -, realistic optimised testing strategies enable such a campaign to be completed in ca. 29 days in the US, 71 in the UK, 25 in Singapore, 17 in Italy and 10 in Germany (ca. eight times faster compared to individual testing). When infection rates are considerably lower, or when employing an optimal, yet logistically more complex pooling method, the gains are more pronounced. Pool-based approaches also reduces the number of false positive diagnoses by 50%. Interpretation: The results of this study provide a clear rationale for adoption of pool-based testing strategies to increase speed and throughput of testing for SARS-CoV-2. The current individual testing approach unnecessarily wastes valuable time and resources.
has issue date	2020-04-24(xsd:dateTime)
has license	arxiv
sha1sum (hex)	d2ed14bc0e1e302886110f07e1bbcc88cbc3e28d
resource representing a document's title	Evaluation of Pool-based Testing Approaches to Enable Population-wide Screening for COVID-19
resource representing a document's body	covid:d2ed14bc0e1e302886110f07e1bbcc88cbc3e28d#body_text
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