About: The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis
Creator	Liu, J Zhang, Y Che, L Pu, Yang
topic	covid:d2f29c0bf8f5b9bf9d357001a62b42244698b298#this
source	PMC
abstract	Enterovirus 71 (EV71) is the major pathogen responsible for fatal hand, foot and mouth disease (HFMD). Our previous work reported on an EV71-infected rhesus monkey infant model that presented with histo-pathologic changes of the central nervous system (CNS) and lungs. This study is focused on the correlated modulation of gene expression in the peripheral blood mononuclear cells (PBMCs) from EV71-infected rhesus monkey infants. The expression of more than 500 functional genes associated with multiple pathways was modulated. The expression of genes associated with immune inflammatory responses was up-regulated during the period from days 4 to 10 post-infection. The expression of two genes (TAC1 and IL17A), which play major roles in inflammatory reactions, was remarkably up-regulated during the infection period. Furthermore, a higher expression level of the TAC1 gene was identified in the CNS compared to the lungs, but a high expression level of the IL-17A gene was observed in the lungs and not in the CNS. The results of this study suggest at least two facts about EV71 infection, which are that: the TAC1 gene that encodes substance P and neurokinin-A is present in both PBMCs and the hypothalamus; and the up-regulation of IL-17A is sustained in the peripheral blood.
has issue date	2014-01-02(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0083766
bibo:pmid	24392094
has license	cc-by
sha1sum (hex)	d2f29c0bf8f5b9bf9d357001a62b42244698b298
schema:url	https://doi.org/10.1371/journal.pone.0083766
resource representing a document's title	The Gene Expression Profile of Peripheral Blood Mononuclear Cells from EV71-Infected Rhesus Infants and the Significance in Viral Pathogenesis
has PubMed Central identifier	PMC3879270
has PubMed identifier	24392094
schema:publication	PLoS One
resource representing a document's body	covid:d2f29c0bf8f5b9bf9d357001a62b42244698b298#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/d2f29c0bf8f5b9bf9d357001a62b42244698b298
is schema:about of	named entity 'IL-17A' named entity 'pathogen' named entity 'IL17A' named entity 'lungs' named entity 'inflammatory responses' named entity 'infected' named entity 'Infected' named entity 'INFECTED' named entity 'RHESUS' named entity 'INFANTS' named entity 'IL17A' named entity 'COMPARED' named entity 'MULTIPLE' named entity 'CNS' named entity 'GENE EXPRESSION PROFILE' named entity 'UP-REGULATED' named entity 'LUNGS' named entity 'HAND' named entity 'ABOUT' named entity 'INFECTED' named entity 'PERIOD' covid:arg/d2f29c0bf8f5b9bf9d357001a62b42244698b298 named entity 'INFLAMMATORY RESPONSES' named entity 'POST' named entity 'IDENTIFIED' named entity 'EXPRESSION' named entity 'HIGH EXPRESSION' named entity 'PBMCS' named entity 'HYPOTHALAMUS' named entity 'RESPONSIBLE' named entity 'CHANGES' named entity 'IL-17A GENE' named entity 'IL-17A' named entity 'PATHOLOGIC' named entity 'RHESUS MONKEY' named entity 'INFECTION' named entity 'HIGHER' named entity 'PERIPHERAL BLOOD' named entity 'MAJOR' named entity 'VIRAL PATHOGENESIS' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'FATAL' named entity 'FUNCTIONAL GENES' named entity 'CORRELATED' named entity 'INFLAMMATORY REACTIONS' named entity 'UP-REGULATION' named entity 'REPORTED' named entity 'PATHOGEN' named entity 'TAC1 GENE' named entity 'EXPRESSION LEVEL' named entity 'MODULATION' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'RESULTS' named entity 'GENES' named entity 'FOOT AND MOUTH DISEASE' named entity 'MODEL' named entity 'MODULATED' named entity 'THE LUNGS' named entity 'PRESENTED' named entity 'OUR' named entity 'PATHWAYS' named entity 'SUGGEST' named entity 'SUSTAINED' named entity 'ENTEROVIRUS 71' named entity 'SUBSTANCE P' named entity 'ASSOCIATED WITH' named entity 'BUT' named entity 'WORK' named entity 'GENE EXPRESSION' named entity 'THE UP' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'IMMUNE' named entity '500' named entity 'MORE THAN' named entity 'NEUROKININ' named entity 'FOCUSED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software