About: Basal Autophagy Is Required for Herpes simplex Virus-2 Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Basal Autophagy Is Required for Herpes simplex Virus-2 Infection
Creator	Shukla, Deepak Yakoub, Abraam
Source	PMC
abstract	Autophagy is a conserved catabolic process of the cell, which plays an important role in regulating plethora of infections. The role of autophagy in Herpes simplex virus-2 (HSV-2) infection is unknown. Here, we found that HSV-2 does not allow induction of an autophagic response to infection, but maintains basal autophagy levels mostly unchanged during productive infection. Thus, we investigated the importance of basal autophagy for HSV-2 infection, using pharmacological autophagy suppression or cells genetically deficient in an autophagy-essential gene (ATG5). Interference with basal autophagy flux in cells significantly reduced viral replication and diminished the infection. These results indicate that basal autophagy plays an indispensable role required for a productive infection. Importantly, this study draws a sharp distinction between induced and basal autophagy, where the former acts as a viral clearance mechanism abrogating infection, while the latter supports infection.
has issue date	2015-08-07(xsd:dateTime)
bibo:doi	10.1038/srep12985
bibo:pmid	26248741
has license	cc-by
sha1sum (hex)	d31b2db65b2e8d40eee096d5e67185099c10c4d2
schema:url	https://doi.org/10.1038/srep12985
resource representing a document's title	Basal Autophagy Is Required for Herpes simplex Virus-2 Infection
has PubMed Central identifier	PMC4528227
has PubMed identifier	26248741
schema:publication	Sci Rep
resource representing a document's body	covid:d31b2db65b2e8d40eee096d5e67185099c10c4d2#body_text
is schema:about of	named entity 'HERPES SIMPLEX VIRUS-2' named entity 'STUDY' named entity 'PHARMACOLOGICAL' covid:arg/d31b2db65b2e8d40eee096d5e67185099c10c4d2 named entity 'INFECTION' named entity 'BASAL' named entity 'MECHANISM' named entity 'ALLOW' named entity 'UNCHANGED' named entity 'SHARP' named entity 'HERE' named entity 'FOUND' named entity 'GENE' named entity 'ACTS' named entity 'INTERFERENCE' named entity 'INFECTION' named entity 'REQUIRED' named entity 'REQUIRED' named entity 'HSV-2' named entity 'WHERE' named entity 'LEVELS' named entity 'AUTOPHAGY' named entity 'OPEN' named entity 'SUPPRESSION' named entity 'BASAL' named entity 'PRODUCTIVE' named entity 'BUT' named entity 'INDUCED' named entity 'RESULTS' named entity 'PLAYS' named entity 'AUTOPHAGY' named entity 'ROLE' named entity 'DIMINISHED' named entity 'CELLS' named entity 'USING' named entity 'RESPONSE TO' named entity 'VIRAL REPLICATION' named entity 'ESSENTIAL' named entity 'INDUCTION' named entity 'DOES NOT' named entity 'INDISPENSABLE' named entity 'FLUX' named entity 'HSV-2 INFECTION' named entity 'THESE' named entity 'REDUCED' named entity 'DEFICIENT' named entity 'INVESTIGATED' named entity 'VIRAL CLEARANCE' named entity 'autophagy' named entity 'pharmacological' named entity 'autophagy' named entity 'Herpes simplex Virus-2' named entity 'autophagic response' named entity 'infection' named entity 'autophagy' named entity 'essential gene' named entity 'autophagy' named entity 'ATG5' named entity 'Infection' named entity 'infection' named entity 'infection' named entity 'infection' named entity 'viral replication' named entity 'infection' named entity 'autophagy' named entity 'autophagy' named entity 'autophagy' named entity 'HSV-2' named entity 'infection' named entity 'HSV-2 infection' nodeID://b56600746 nodeID://b56948338 nodeID://b57372082 nodeID://b57505218 nodeID://b57667018 nodeID://b58179610 nodeID://b58186922 nodeID://b58187102 nodeID://b58188130 nodeID://b58191174

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