About: Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto

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About: Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto
Creator	Wang, Lin-Fa Shi, Zhengli Zhou, Peng Cowled, Chris Marsh, Glenn Baker, Michelle
Source	Medline; PMC
abstract	Bats are rich reservoir hosts for a variety of viruses, many of which are capable of spillover to other susceptible mammals with lethal consequences. The ability of bats to remain asymptomatic to viral infection may be due to the rapid control of viral replication very early in the immune response through innate antiviral mechanisms. Type I and III interferons (IFNs) represent the first line of defence against viral infection in mammals, with both families of IFNs present in pteropid bats. To obtain further insight into the type III IFN system in bats, we describe the characterization of the type III IFN receptor (IFNλR) in the black flying fox, P. alecto with the characterization of IFNλR1 and IL10R2 genes that make up the type III IFN receptor complex. The bat IFNλR complex has a wide tissue distribution and at the cellular level, both epithelial and immune cells are responsive to IFN-λ treatment. Furthermore, we demonstrate that the bat IFNλR1 chain acts as a functional receptor. To our knowledge, this report represents the first description of an IFN receptor in any species of bat. The responsiveness of bat cells to IFN-λ support a role for the type III IFN system by epithelial and immune cells in bats.
has issue date	2011-09-27(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0025385
bibo:pmid	21980438
has license	cc-by
sha1sum (hex)	d336ffee34085032c158363c77b69204c58ca85a
schema:url	https://doi.org/10.1371/journal.pone.0025385
resource representing a document's title	Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto
has PubMed Central identifier	PMC3181264
has PubMed identifier	21980438
schema:publication	PLoS One
resource representing a document's body	covid:d336ffee34085032c158363c77b69204c58ca85a#body_text
is schema:about of	named entity 'PTEROPUS ALECTO' named entity 'cells' named entity 'Bats' named entity 'black flying fox' named entity 'complex' named entity 'bats' named entity 'lethal consequences' named entity 'Characterisation' named entity 'Bat' named entity 'Functional' named entity 'alecto' named entity 'BAT' named entity 'SYSTEM' named entity 'MAMMALS' named entity 'GENES' named entity 'MAKE' named entity 'CHAIN' named entity 'TYPE I' named entity 'FAMILIES' named entity 'DUE TO' named entity 'VARIETY' named entity 'IMMUNE RESPONSE' named entity 'LINE' named entity 'BAT' named entity 'REPORT' named entity 'CONSEQUENCES' named entity 'ASYMPTOMATIC' named entity 'VIRAL INFECTION' named entity 'VIRUSES' named entity 'IFN' named entity 'RICH' named entity 'SPECIES' named entity 'RECEPTOR COMPLEX' named entity 'IMMUNE CELLS' named entity 'COMPLEX' named entity 'TREATMENT' named entity 'DESCRIBE' named entity 'CELLS' named entity 'EPITHELIAL' named entity 'INSIGHT' named entity 'INTERFERONS' named entity 'MAY BE' named entity 'RESPONSIVE TO' named entity 'MECHANISMS' named entity 'IFN' named entity 'SUPPORT' named entity 'EARLY' named entity 'TYPE III' named entity 'RECEPTOR EXPRESSION' named entity 'FUNCTIONAL' named entity 'IL10R2' named entity 'FUNCTIONAL' named entity 'LETHAL' named entity 'CAPABLE' named entity 'DESCRIPTION' named entity 'TISSUE DISTRIBUTION' named entity 'CHARACTERIZATION' named entity 'KNOWLEDGE' named entity 'ANTIVIRAL' named entity 'RAPID' named entity 'ACTS' named entity 'III' named entity 'OBTAIN' named entity 'IFNLR1' named entity 'TYPE III' named entity 'LEVEL' named entity 'VIRAL REPLICATION' named entity 'WIDE' named entity 'BATS' named entity 'CELLULAR' named entity 'SPILLOVER' named entity 'PRESENT' named entity 'RESERVOIR' named entity 'SUSCEPTIBLE' named entity 'HOSTS' named entity 'RECEPTOR'

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