About: Spike protein assembly into the coronavirion: exploring the limits of its sequence requirements

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About: Spike protein assembly into the coronavirion: exploring the limits of its sequence requirements Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Spike protein assembly into the coronavirion: exploring the limits of its sequence requirements
Creator	Rottier, Peter Bosch, Jan De Haan, Cornelis Smits, Saskia
Source	Elsevier; Medline; PMC
abstract	Abstract The coronavirus spike (S) protein, required for receptor binding and membrane fusion, is incorporated into the assembling virion by interactions with the viral membrane (M) protein. Earlier we showed that the ectodomain of the S protein is not involved in this process. Here we further defined the requirements of the S protein for virion incorporation. We show that the cytoplasmic domain, not the transmembrane domain, determines the association with the M protein and suffices to effect the incorporation into viral particles of chimeric spikes as well as of foreign viral glycoproteins. The essential sequence was mapped to the membrane-proximal region of the cytoplasmic domain, which is also known to be of critical importance for the fusion function of the S protein. Consistently, only short C-terminal truncations of the S protein were tolerated when introduced into the virus by targeted recombination. The important role of the about 38-residues cytoplasmic domain in the assembly of and membrane fusion by this approximately 1300 amino acids long protein is discussed.
has issue date	2005-04-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2005.02.001
bibo:pmid	15780881
has license	els-covid
sha1sum (hex)	d3592733f4805cdd0a1daa4a39a9099f106eb1ea
schema:url	https://doi.org/10.1016/j.virol.2005.02.001
resource representing a document's title	Spike protein assembly into the coronavirion: exploring the limits of its sequence requirements
has PubMed Central identifier	PMC7111810
has PubMed identifier	15780881
schema:publication	Virology
resource representing a document's body	covid:d3592733f4805cdd0a1daa4a39a9099f106eb1ea#body_text
is schema:about of	named entity 'EARLIER' named entity 'EFFECT' named entity 'ASSEMBLING' named entity 'AMINO ACIDS' named entity 'TRANSMEMBRANE DOMAIN' named entity 'FUNCTION' named entity 'RECOMBINATION' named entity 'TARGETED' named entity 'VIRAL MEMBRANE' named entity '1300' named entity 'CHIMERIC' named entity 'MAPPED' named entity 'PROTEIN ' named entity 'LONG' named entity 'NOT INVOLVED' named entity 'mapped' named entity 'C-terminal' named entity 'membrane fusion' named entity 'introduced' named entity 'binding' named entity 'chimeric' named entity 'SPIKE PROTEIN' named entity 'LIMITS' named entity 'REQUIREMENTS' named entity 'ASSOCIATION' named entity 'S PROTEIN' named entity 'EXPLORING' named entity 'REQUIREMENTS' named entity 'SPIKES' named entity 'C-TERMINAL' named entity 'RECEPTOR BINDING' named entity '28S' named entity 'GLYCOPROTEINS' named entity 'INTRODUCED INTO' named entity 'M PROTEIN' named entity 'SHORT' named entity 'ESSENTIAL' named entity 'CRITICAL' named entity 'FOREIGN' named entity 'ITS SEQUENCE' named entity 'PROTEIN ASSEMBLY' named entity 'ASSEMBLY' named entity 'ROLE' named entity 'MEMBRANE' named entity 'ABOUT' named entity 'PROCESS' named entity 'KNOWN' named entity 'PROXIMAL REGION' named entity 'MEMBRANE FUSION' named entity 'VIRAL' named entity 'INTERACTIONS' named entity 'CORONAVIRUS' named entity 'VIRUS' named entity 'IMPORTANT' named entity 'SPIKE' named entity 'HERE' named entity 'FUSION' named entity 'REQUIRED' named entity 'APPROXIMATELY' named entity 'ECTODOMAIN' named entity 'VIRION' named entity 'VIRAL PARTICLES' named entity 'DEFINED' named entity 'PROTEIN' named entity 'CYTOPLASMIC DOMAIN' named entity 'SEQUENCE' named entity 'membrane fusion' named entity 'receptor' named entity 'receptor binding' named entity 'viral membrane' named entity 'recombination' named entity 'cytoplasmic domain' named entity 'ectodomain' named entity 'membrane fusion' named entity 'streptomycin' named entity 'coding region' named entity 'cytoplasmic domain' named entity 'protein'

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