About: Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies

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About: Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies
Creator	Rottier, Peter Raaben, Matthijs De Haan, Cornelis Koerkamp, Marian
source	Medline; PMC
abstract	Many viruses, including coronaviruses, induce host translational shutoff, while maintaining synthesis of their own gene products. In this study we performed genome‐wide microarray analyses of the expression patterns of mouse hepatitis coronavirus (MHV)‐infected cells. At the time of MHV‐induced host translational shutoff, downregulation of numerous mRNAs, many of which encode protein translation‐related factors, was observed. This downregulation, which is reminiscent of a cellular stress response, was dependent on viral replication and caused by mRNA decay. Concomitantly, phosphorylation of the eukaryotic translation initiation factor 2α was increased in MHV‐infected cells. In addition, stress granules and processing bodies appeared, which are sites for mRNA stalling and degradation respectively. We propose that MHV replication induces host translational shutoff by triggering an integrated stress response. However, MHV replication per se does not appear to benefit from the inhibition of host protein synthesis, at least in vitro, since viral replication was not negatively affected but rather enhanced in cells with impaired translational shutoff.
has issue date	2007-04-13(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2007.00951.x
bibo:pmid	17490409
has license	no-cc
sha1sum (hex)	d380773627e53861619e10e667632f739e965edc
schema:url	https://doi.org/10.1111/j.1462-5822.2007.00951.x
resource representing a document's title	Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies
has PubMed Central identifier	PMC7162177
has PubMed identifier	17490409
schema:publication	Cell Microbiol
resource representing a document's body	covid:d380773627e53861619e10e667632f739e965edc#body_text
is schema:about of	named entity 'reminiscent' named entity 'MHV' named entity 'STRESS' named entity 'GRANULES' named entity 'INCREASED' named entity 'MHV' named entity 'PHOSPHORYLATION' named entity 'MOUSE HEPATITIS' named entity 'ENCODE' named entity 'PROCESSING' named entity 'SYNTHESIS' named entity 'MRNA DECAY' named entity 'CELLULAR STRESS RESPONSE' named entity 'MRNAS' named entity 'ENHANCED' named entity 'HOST' covid:arg/d380773627e53861619e10e667632f739e965edc named entity 'numerous' named entity 'microarray' named entity 'encode' named entity 'host' named entity 'infected' named entity 'MHV' named entity 'processing bodies' named entity 'translational' named entity 'viral replication' named entity 'performed' named entity 'translational' named entity 'mRNAs' named entity 'stress granules' named entity 'viral replication' named entity 'viral replication' named entity 'downregulation' named entity 'stress granules' named entity 'coronavirus' named entity 'processing bodies' named entity 'cells' named entity 'mRNAs' named entity 'mRNAs' named entity 'Cxcl2' named entity 'mRNA' named entity 'mRNA' named entity 'inhibition of protein synthesis' named entity 'MHV' named entity 'embryo' named entity 'IgG' named entity 'transcription inhibitor' named entity 'mRNA' named entity 'infection' named entity 'Sindbis' named entity 'downregulation' named entity 'LR7' named entity 'viral replication' named entity 'NF-kB' named entity 'RNA binding proteins' named entity 'metabolic' named entity 'ribosome biogenesis' named entity 'infection' named entity 'polyclonal antibody' named entity 'translational machinery' named entity 'severe acute respiratory syndrome' named entity 'cellular stress response' named entity 'MHV' named entity 'eIF2a' named entity 'w/v' named entity 'mRNA' named entity 'eIF2a' named entity 'MHV' named entity 'protein' named entity 'hybridization' named entity 'viral RNA' named entity 'luciferase' named entity 'phosphatase' named entity 'UV light' named entity 'yeast' named entity 'phosphorylation' named entity 'RT-PCR' named entity 'transcription factor'

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